PFGE analysis of Listeria monocytogenes isolates of clinical, animal, food and environmental origin from Ireland
PFGE analysis of Listeria monocytogenes isolates of clinical, animal, food and environmental origin from Ireland
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DOI：
10.1099/jmm.0.036764-0
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发表时间：
2012-04-01
影响因子：
3
通讯作者：
Jordan, Kieran
中科院分区：
文献类型：
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作者：
Fox, Edward M.;deLappe, Niall;Jordan, Kieran
单核细胞增生李斯特菌是一种重要的食源性致病菌。人类感染与高死亡率有关。流行病学调查和分子分型可有助于将人类疾病与特定感染源联系起来。本回顾性研究描述了在爱尔兰使用PFGE来检查222个来自人类和非人类来源的分离株的关系。还检查了来自其他国家的人类临床分离株。检测到8个彼此难以区分的人类和非人类分离株（主要是血清型4b）小簇，提示人类感染的潜在来源。对于非人类分离株，某些类型的PFGE似乎只与单一来源相关，而其他类型的PFGE似乎传播得更广泛。难以区分或高度相关的爱尔兰和非爱尔兰源分离群表明，一些PFGE模式可能在全球分布。
Listeria monocytogenes is an important foodborne human pathogen. Human infection is associated with high mortality rates. Epidemiological investigation and molecular subtyping can be useful in linking human illness with specific sources of infection. This retrospective study describes the use of PFGE to examine relationships of 222 isolates from human and non-human sources in Ireland. Human clinical isolates from other countries were also examined. Eight small clusters of human and non-human isolates (mostly serotype 4b) that were indistinguishable from one another were detected, suggesting potential sources for human infection. For non-human isolates, some PFGE types appeared to be exclusively associated with a single source, whereas other PFGE-types appeared to be more widely disseminated. Indistinguishable, or highly related clusters of isolates of Irish and non-Irish origin suggest that some PFGE patterns may be globally distributed.