Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13.
Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13.
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发表时间：
2007
期刊：
影响因子：
56.9
通讯作者：
H. Melichar;Kavitha Narayan;S. Der;Y. Hiraoka;N. Gardiol;Grégoire Jeannet;W. Held;C. Chambers
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文献类型：
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作者：
H. Melichar;Kavitha Narayan;S. Der;Y. Hiraoka;N. Gardiol;Grégoire Jeannet;W. Held;C. Chambers
alphabeta and gammadelta T cells originate from a common, multipotential precursor population in the thymus, but the molecular mechanisms regulating this lineage-fate decision are unknown. We have identified Sox13 as a gammadelta-specific gene in the immune system. Using Sox13 transgenic mice, we showed that this transcription factor promotes gammadelta T cell development while opposing alphabeta T cell differentiation. Conversely, mice deficient in Sox13 expression exhibited impaired development of gammadelta T cells but not alphabeta T cells. One mechanism of SOX13 function is the inhibition of signaling by the developmentally important Wnt/T cell factor (TCF) pathway. Our data thus reveal a dominant pathway regulating the developmental fate of these two lineages of T lymphocytes.
