DECREASED ACTIVITY OF SCAVENGER ENZYMES IN HUMAN HEPATOCELLULAR-CARCINOMA, BUT NOT IN LIVER METASTASES
DECREASED ACTIVITY OF SCAVENGER ENZYMES IN HUMAN HEPATOCELLULAR-CARCINOMA, BUT NOT IN LIVER METASTASES
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DOI：
10.1007/bf02593907
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发表时间：
1994-05-01
期刊：
影响因子：
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通讯作者：
CORROCHER, R
中科院分区：
文献类型：
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作者：
CASARIL, M;CORSO, F;CORROCHER, R
为了研究氧自由基在肝细胞癌中的作用，我们检测了 19 名对照患者、23 例肝细胞癌和 18 例不同癌症肝转移病例的肝匀浆中的组织清除酶（超氧化物歧化酶和硒依赖性谷胱甘肽过氧化物酶）、维生素 A 和 E 的血浆浓度以及血清硒水平。在肝细胞癌组织中，酶活性均显着低于对照肝脏和转移性肝脏；后者组织的酶活性与对照肝脏没有差异。相反，与肝细胞癌相邻的正常肝脏的超氧化物歧化酶活性降低。肝细胞癌和肝转移患者血清硒浓度显着降低，而维生素A仅在前者显着降低。这些发现表明，肝细胞癌在细胞抗氧化系统严重受损的肝脏中发展，因为在来自不同癌症的肝转移患者中，尽管硒浓度较低，细胞清除酶仍具有正常活性。
To investigate the role of oxygen free radicals in hepatocellular carcinoma we assayed tissue scavenger enzymes (superoxide dismutase and selenium-dependent glutathione peroxidase) in liver homogenate, plasma concentrations of vitamins A and E and the serum selenium level from 19 control patients, 23 cases of hepatocellular carcinoma and 18 cases of metastases to liver from different carcinomas. In hepatocellular carcinoma tissue the enzyme activities were all significantly lower than in control liver and in metastases-bearing liver; the enzyme activities of the latter tissues were not different from control liver. In contrast, normal liver adjacent to the hepatocellular carcinoma had decreased activity of superoxide dismutase. Serum selenium concentrations were significantly decreased in patients with hepatocellular carcinoma and those with liver metastases, while vitamin A was significantly decreased only in the former. These findings suggest that hepatocellular carcinoma develops in liver with severe impairment of cellular antioxidant systems, since, in patients with liver metastases from different cancers, despite low selenium concentrations, cellular scavenger enzymes have normal activities.