Nitrous oxide neurotoxicity studies in man and rat.
Nitrous oxide neurotoxicity studies in man and rat.
复制标题
一氧化二氮对人和大鼠的神经毒性研究。
DOI：
10.1097/00000542-198009000-00005
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发表时间：
1980
期刊：
影响因子：
8.8
通讯作者：
Skau,KA
中科院分区：
文献类型：
--
作者：
Dyck,PJ;Grina,LA;Lambert,EH;Calder,CS;Oviatt,K;Rehder,K;Lund,BA;Skau,KA
为了评估长期暴露于低水平的一氧化二氮对人类神经功能的影响，作者评估了明尼苏达州罗切斯特市大约一半的牙医的神经状况、运动和感觉神经传导，以及感觉的计算机测试。在实践中广泛使用一氧化二氮的牙医和不使用一氧化二氮的牙医的神经功能评分测试结果没有显著差异。为了评估长期暴露于高浓度氧化亚氮对实验动物神经功能和结构的影响，一组大鼠在6个月的时间里，每周5天，连续4小时暴露于含70%氧化亚氮和30%氧气的环境中。N2O暴露大鼠与对照大鼠在幸福感、尾神经传导、乙酰胆碱酯酶和多巴胺- β -羟化酶的轴突含量和转运、戏弄髓鞘纤维的数量、大小分布和病理异常方面均无差异。虽然这些结果表明N2O在大鼠中缺乏周围神经毒性，但我们不能假设在大量暴露的人中也没有类似的神经毒性。
To assess the effects of chronic exposure to low levels of nitrous oxide on neural function of man, the authors evaluated the neurologic condition, motor and sensory nerve conduction, and computerized tests of sensation of approximately half of the dentists in Rochester, Minnesota. Results of scored tests of neural function were not significantly different for dentists who used nitrous oxide extensively in their practices and dentists who did not. To assess the effects of chronic exposure to high levels of nitrous oxide on neural function and structure of experimental animals, groups of rats were exposed to 70 per cent N2O in 30 per cent oxygen for four hours, five days a week, for six months. Rats exposed to N2O and control rats showed no difference in well-being, in caudal nerve conduction, in axonal content and transport of acetylcholinesterase and dopamine-beta-hydroxylase, or in number and size distribution and pathologic abnormality of teased myelinated fibers. Although these results indicate a lack of peripheral nerve neurotoxicity of N2O in the rat, one cannot assume a similar lack of neurotoxicity in man with heavy exposures.