Chronic iron overload and toxicity: clinical chemistry perspective.
Chronic iron overload and toxicity: clinical chemistry perspective.
复制标题
慢性铁过载和毒性：临床化学视角。
DOI：
--
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
J. Kang
中科院分区：
文献类型：
--
作者：
J. Kang
人体铁的含量主要通过吸收来调节，因为人体没有多余的铁排泄的生理机制。然而，这一规定并不是绝对的。许多因素，如饮食的含量，铁的剂量，生活方式等影响铁的吸收。在过去，由于世界范围内铁缺乏的严重性，强化铁的营养计划和摄入铁制剂已经被广泛实践。此外，我们现在知道，大量无症状的人携带血色素沉着症基因，HFE，这表明这些人有可能在他们的一生中积累过多的体内铁。过量的体内铁是剧毒的。这种毒性涉及许多器官，导致各种严重疾病，如肝病、心脏病、糖尿病、激素异常、免疫系统功能障碍等。与铁超载相关的组织损伤被认为主要是由铁介导的自由基反应引起的。铁是自由基反应的有效催化剂。与铁超载有关的疾病可以得到有效管理或预防。因此，铁超载的早期诊断和适当的治疗至关重要。通过提供必要的实验室数据，临床化学实验室可以在这些健康问题的管理中发挥关键作用。
The content of body iron is regulated primarily by absorption since humans have no physiological mechanism by which excess iron is excreted. This regulation, however, is not absolute. Many factors such as the content of diets, iron doses, life styles, etc. influence iron absorption. In the past, nutrition programs for iron fortification and the ingestion of iron preparations have been widely practiced because of the seriousness of worldwide iron deficiency. Also, we now know that a significant number of asymptomatic people carry the hemochromatosis gene, HFE, indicating that these people have the potential to accumulate excess body iron in their lifetime. Excess body iron can be highly toxic. This toxicity involves many organs leading to a variety of serious diseases such as liver disease, heart disease, diabetes mellitus, hormonal abnormalities, dysfunctional immune system, etc. The tissue damage associated with iron overload is believed to result primarily from free radical reactions mediated by iron. Iron is an effective catalyst in free radical reactions. The diseases associated with iron overload can be managed effectively or prevented. Therefore, early diagnosis of iron overload and appropriate therapy are critical. By providing the necessary laboratory data, clinical chemistry laboratories can play the pivotal role in the management of these health problems.