Relative weight and risk of breast cancer among premenopausal women.
Relative weight and risk of breast cancer among premenopausal women.
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绝经前女性的相对体重和乳腺癌风险。
DOI：
10.1093/oxfordjournals.aje.a114156
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发表时间：
1985
影响因子：
5
通讯作者：
Speizer,FE
中科院分区：
文献类型：
--
作者：
Willett,WC;Browne,ML;Bain,C;Lipnick,RJ;Stampfer,MJ;Rosner,B;Colditz,GA;Hennekens,CH;Speizer,FE
尽管通常认为较高的相对体重会增加患乳腺癌的风险，但几项病例对照研究表明，在绝经前女性中，情况可能恰恰相反。因此，在1976年对121，964名年龄在30-55岁之间的美国女性进行的4年随访中，研究了Quetelot指数（以体重/身高2计算的相对体重的量度）与随后的乳腺癌发病率之间的关联。与经历过自然绝经或双侧卵巢切除术的女性相比，绝经前女性乳腺癌的发病率随着相对体重水平的升高而降低，Quetelef指数增加五分位数的经t检验调整的相对风险分别为1.00、0.90、0.90、0.73和0.66（趋势的Mantel扩展检验=-2.82，p = 0.005）。已知的乳腺癌风险因素不能解释这种负相关，当使用18岁时报告的体重计算Quetelef指数时，这种负相关性更强。然而，绝经前瘦女性乳腺癌的过度发病率仅限于直径小于2.0 cm、与淋巴结转移无关且分化良好的肿瘤。这些研究结果表明，绝经前瘦女性患乳腺癌的明显过度风险可能至少部分来自于更容易，因此更早诊断侵袭性较低的肿瘤。
Although higher relative weight is generally considered to increase the risk of breast cancer, several case-control studies have suggested that the reverse may be true among premenopausal women. The association between Quetelot's index (a measure of relative weight calculated as weight/height2) and the subsequent incidence of breast cancer was therefore examined during four years of follow-up among a cohort of 121,964 US women who were 30–55 years of age in 1976. In contrast to women who had experienced natural menopause or bilateral oophorectomy, the incidence of breast cancer among premenopausal women decreased with higher levels of relative weight Age-adjusted relative risks for increasing quintiles of Quetelef s index were 1.00, 0.90, 0.90, 0.73, and 0.66 (Mantel extension test for trend =−2.82,p= 0.005). This inverse association was not explained by known risk factors for breast cancer and was somewhat stronger when Quetelef s index was computed using reported weight at age 18 years. The excess incidence of breast cancer among lean premenopausal women, however, was limited to tumors that were less than 2.0 cm in diameter, were not associated with metastases to lymph nodes, and were well-differentiated. These findings suggest that the apparent excess risk of breast cancer among lean premenopausal women may result at least in part from easier, and thus earlier, diagnosis of less aggressive tumors.