The multiple risk factor intervention trial (MRFIT). VII. A comparison of risk factor changes between the two study groups.
The multiple risk factor intervention trial (MRFIT). VII. A comparison of risk factor changes between the two study groups.
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多危险因素干预试验（MRFIT）。
DOI：
10.1016/0091-7435(81)90063-3
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发表时间：
1981
影响因子：
5.1
通讯作者：
J. Schoenberger
中科院分区：
文献类型：
--
作者：
J. Neaton;S. Broste;L. Cohen;E. Fishman;M. Kjelsberg;J. Schoenberger
将MRFIT特殊干预（SI）参与者4年内的风险因素变化与家庭护理（UC）参与者的风险因素变化进行比较。将两个研究组之间的差异与原始设计假设进行比较。4年随访后，血清胆固醇差异平均为预测值的50%;两个研究组之间的舒张压差异平均为预测值的67%;特殊干预组相对于家庭护理组的吸烟减少超过了每年基于报告病史的预测。当血清硫氰酸盐用于验证报告的停止时，SI-UC差异减小，但平均值仍大于随访第三和第四年预测的降低。
Risk factor changes over 4 years for MRFIT Special Intervention (SI) participants are compared with risk factor changes made by Usual Care (UC) participants. Differences between the two study groups are compared with original design assumptions. After 4 years of follow-up, serum cholesterol differences averaged 50% of what was predicted; diastolic blood pressure differences between the two study groups averaged 67% of that predicted; cigarette smoking reductions in the Special Intervention group relative to the Usual Care group have exceeded what was predicted each year based on reported histories. When serum thiocyanate is used to verify reported cessation the SI-UC difference is reduced but still averages greater than the reductions predicted in the third and fourth years of follow-up.