Vaccinia virus preferentially infects and controls human and murine ovarian tumors in mice
Vaccinia virus preferentially infects and controls human and murine ovarian tumors in mice
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DOI：
10.1038/sj.gt.3302840
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发表时间：
2007-01-01
期刊：
影响因子：
5.1
通讯作者：
Wu, T-C
中科院分区：
文献类型：
--
作者：
Hung, C-F;Tsai, Y-C;Wu, T-C
牛痘病毒已被证明能有效感染肿瘤细胞。因此，牛痘病毒是一种潜在的安全有效的抗卵巢癌的抗肿瘤药物。在这里，我们评估了牛痘病毒优先感染和控制人类和小鼠体内卵巢肿瘤的能力。我们用非侵入性发光成像系统监测了活鼠卵巢肿瘤的感染和抑制。我们的数据表明，牛痘能够有效地感染和杀死人类和小鼠卵巢肿瘤。经腹腔注射给小鼠的牛痘病毒特异性靶向小鼠或人卵巢肿瘤，并导致抗肿瘤反应。这些发现表明，牛痘病毒能够选择性地靶向和控制卵巢肿瘤。因此，腹腔注射牛痘病毒可能为治疗晚期卵巢癌提供一种潜在的有效策略。
Vaccinia virus has been shown to efficiently infect tumor cells. Therefore, vaccinia virus represents a potentially safe and effective antitumor agent against ovarian cancer. Here, we assessed the ability of vaccinia virus to preferentially infect and control both human and murine ovarian tumors in vivo. We used the non-invasive luminescence imaging system to monitor the infection and suppression of ovarian tumors by vaccinia in live mice. Our data indicated that vaccinia was able to effectively infect and kill both human and murine ovarian tumors. Vaccinia virus administered to mice intraperitoneally was specifically targeted to the murine or human ovarian tumors and led to antitumor responses. These findings suggest that vaccinia virus is capable of selectively targeting and controlling ovarian tumors. Thus, intraperitoneal injection with vaccinia virus may provide a potentially effective strategy for treating advanced-stage ovarian cancers.