The use of osteogenic protein-1 in reconstructive surgery of the hip
The use of osteogenic protein-1 in reconstructive surgery of the hip
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DOI：
10.1054/arth.2001.28363
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发表时间：
2001-12-01
影响因子：
3.5
通讯作者：
Carvajal, JP
中科院分区：
文献类型：
--
作者：
Cook, SD;Barrack, RL;Carvajal, JP
成骨蛋白（OP），也称为骨形态发生蛋白（BMP），是骨基质多肽家族，其诱导导致新骨形成的一系列细胞事件。本文报道了重组人OP-1（rhOP-1，rhBMP-7）在临床前动物模型中的应用以及在髋关节重建手术中的初步人类临床经验。在临床前模型中，rhOP-1与粉碎的松质骨和皮质支柱同种异体移植物联合使用显著改善了移植物的生物活性，导致更大和更早的新骨形成和移植物结合。rhOP-1在髋关节重建手术中的临床应用也导致了在更具挑战性的生物环境中与单独的同种异体骨相比更大和更早的新骨形成。
Osteogenic proteins (OPs), also referred to as bone morphogenetic proteins (BMPs), are a family of bone matrix polypeptides that induce a sequence of cellular events that lead to the formation of new bone. This article reports the use of recombinant human OP-1 (rhOP-1, rhBMP-7) in preclinical animal models and initial human clinical experience in hip reconstructive surgery. The use of rhOP-1 in conjunction with morcellized cancellous bone and cortical strut allograft in preclinical models dramatically improved the biologic activity of the graft, resulting in greater and earlier new bone formation and graft incorporation. The clinical use of rhOP-1 in hip reconstructive procedures also resulted in greater and earlier new bone formation in the more challenging biologic environment compared with allograft bone alone.