BRAIN SEROTONERGIC ACTIVITY AND PLASMA AMINO-ACID LEVELS IN GENETICALLY-OBESE ZUCKER RATS
BRAIN SEROTONERGIC ACTIVITY AND PLASMA AMINO-ACID LEVELS IN GENETICALLY-OBESE ZUCKER RATS
复制标题
DOI：
10.1016/0091-3057(82)90476-2
复制
发表时间：
1982-01-01
影响因子：
3.6
通讯作者：
FISCHER, JE
中科院分区：
文献类型：
--
作者：
FINKELSTEIN, JA;CHANCE, WT;FISCHER, JE
为了检验遗传性肥胖Zucker大鼠脑中羟色胺能活动异常的假设，在肥胖和非肥胖雄性大鼠组的8个脑区域中测量了5-羟色胺（5-HT）、其氨基酸前体色氨酸（Trp）及其主要代谢物5-羟基IAA（5-HIAA）的水平。还在相同动物中测定了血浆白蛋白水平以及血浆和皮质样品中氨基酸和相关化合物的水平。虽然色氨酸在肥胖动物的几个大脑区域中较慢，但肥胖组中显示5-HT水平降低的唯一区域是中脑。肥胖动物间脑中的5-HIAA含量也较低，但其他差异不显著。在肥胖动物中观察到皮质氨基酸水平升高和降低。肥胖组血浆白蛋白水平升高。肥胖大鼠血浆中游离Trp减少，而与Trp竞争运输穿过血脑屏障的其他氨基酸（Met、Leu、Ile、瓦尔和Phe）水平升高。较低的血浆游离色氨酸和竞争性氨基酸水平增加的组合似乎有助于降低遗传性肥胖大鼠脑中色氨酸水平。
To test the hypothesis that serotonergic activity is abnormal in the brains of genetically obese Zucker rats, levels of serotonin (5-HT), its amino acid precursor tryptophan (Trp) and its major metabolite 5-hydroxy IAA (5-HIAA) were measured in 8 brain regions in groups of obese and nonobese male rats. Plasma albumin levels as well as levels of amino acids and related compounds in plasma and in a cortical sample were also determined in the same animals. While Trp was slower in several brain regions of the obese animals, the only region showing a depressed level of 5-HT in the obese group was the mesencephalon. Obese animals also had a lower amount of 5-HIAA in the diencephalon, but no other differences were significant. Both elevations and depressions were observed in cortical amino acid levels in obese animals. The level of plasma albumin was increased in the obese group. Free Trp was decreased in the plasma of obese rats while levels of other amino acids (Met, Leu, Ile, Val and Phe) which compete with Trp for transport across the blood-brain barrier were elevated. The combination of lower plasma free Trp and increased levels of competitive amino acids appears to contribute to decreased levels of Trp in the brain of genetically obese rats.