Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID-19
Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID-19
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DOI：
10.1111/cea.13997
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发表时间：
2021-08-12
影响因子：
6.1
通讯作者：
Butnaru, Denis
中科院分区：
文献类型：
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作者：
Munblit, Daniel;Bobkova, Polina;Butnaru, Denis
背景COVID-19的长期后遗症仍然没有得到很好的表征。我们评估了先前住院的COVID-19患者的持续症状，并评估了潜在的风险因素。方法收集2020年4月8日至7月10日期间从俄罗斯莫斯科4家医院出院的患者数据。参与者通过电话采访使用ISARIC长期随访研究问卷。结果4755名出院患者中有2，649名（56%）在出院后中位218（IQR 200，236）天成功接受评估。COVID-19诊断为临床1291例，分子1358例。大多数病例为轻度，但902例（34%）需要补充氧气，68例（2.6%）需要呼吸支持。中位年龄为56岁（IQR 46，66），1，353例（51.1%）为女性。1247名（47.1%）参与者报告了持续性症状，其中疲劳（21.2%），呼吸急促（14.5%）和健忘（9.1%）是最常见的症状，慢性疲劳（25%）和呼吸（17.2%）是最常见的症状类别。女性与任何持续性症状类别相关，OR 1.83（95% CI 1.55 - 2.17），其中皮肤病（3.26，2.36 - 4.57）症状的相关性最强。哮喘和慢性肺部疾病总体上与持续症状无关，但哮喘与神经系统（1.95，1.25至2.98）以及情绪和行为变化（2.02，1.24至3.18）相关，慢性肺部疾病与慢性疲劳（1.68，1.21至2.32）相关。结论近一半因COVID-19住院的成年人在出院后6至8个月报告持续症状。疲劳和呼吸道症状最常见，女性与持续症状相关。
Background The long-term sequalae of COVID-19 remain poorly characterized. We assessed persistent symptoms in previously hospitalized patients with COVID-19 and assessed potential risk factors. Methods Data were collected from patients discharged from 4 hospitals in Moscow, Russia between 8 April and 10 July 2020. Participants were interviewed via telephone using an ISARIC Long-term Follow-up Study questionnaire. Results 2,649 of 4755 (56%) discharged patients were successfully evaluated, at median 218 (IQR 200, 236) days post-discharge. COVID-19 diagnosis was clinical in 1291 and molecular in 1358. Most cases were mild, but 902 (34%) required supplemental oxygen and 68 (2.6%) needed ventilatory support. Median age was 56 years (IQR 46, 66) and 1,353 (51.1%) were women. Persistent symptoms were reported by 1247 (47.1%) participants, with fatigue (21.2%), shortness of breath (14.5%) and forgetfulness (9.1%) the most common symptoms and chronic fatigue (25%) and respiratory (17.2%) the most common symptom categories. Female sex was associated with any persistent symptom category OR 1.83 (95% CI 1.55 to 2.17) with association being strongest for dermatological (3.26, 2.36 to 4.57) symptoms. Asthma and chronic pulmonary disease were not associated with persistent symptoms overall, but asthma was associated with neurological (1.95, 1.25 to 2.98) and mood and behavioural changes (2.02, 1.24 to 3.18), and chronic pulmonary disease was associated with chronic fatigue (1.68, 1.21 to 2.32). Conclusions Almost half of adults admitted to hospital due to COVID-19 reported persistent symptoms 6 to 8 months after discharge. Fatigue and respiratory symptoms were most common, and female sex was associated with persistent symptoms.