Memory-enhancing effects of DHEAS in aged mice on a win-shift water escape task
Memory-enhancing effects of DHEAS in aged mice on a win-shift water escape task
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DOI：
10.1016/s0031-9384(00)00446-7
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发表时间：
2001-03-01
影响因子：
2.9
通讯作者：
Locurto, C
中科院分区：
文献类型：
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作者：
Markowski, M;Ungeheuer, M;Locurto, C
类固醇激素脱氢表雄酮(DHEA)及其硫酸盐(DHEAS)与年龄相关的记忆缺陷有关。许多研究已经证明了这些神经类固醇可以有效地增强记忆保持和改善各种记忆阻滞剂的效果，但很少有研究直接测试它们对老年动物记忆的影响。本研究利用水逃避动机研究了DHEAS在Win-Shift(不匹配到样本)任务中对老年小鼠记忆的增强作用。16只18-20个月大的CD-1小鼠被训练成7/10正确试验的中等标准，然后根据获得性能被分成两组。其中一组在0.0015%水杨酸甲酯溶液中口服DHEAS(1.5毫克/只/天)，而另一组只接受赋形剂。通过在三个测试阶段的样本和对照试验之间插入延迟间隔(0、20和240 S)的程序来评估DHEAS的效果。接受DHEAS的那一组在3天的测试中记录了显著更高的保持分数，特别是在120-S延迟时间间隔，这表明DHEAS增强了这些老年动物的工作记忆。(C)2001 Elsevier Science Inc.保留所有权利。
The steroid hormone, dehydroepiandrosterone (DHEA) and its sulfate DHEAS) have been implicated in age-associated deficits in memory. Numerous studies have demonstrated the effectiveness of these neurosteroids to enhance retention and meliorate the effects of various memory-blocking agents, but few studies have directly assayed their effects on memory in aged animals. The present study investigated the memory-enhancing effects of DHEAS in a win-shift (nonmatching-to-sample) task in aged mice using water escape motivation. Sixteen CD-1 mice, 18-20 months old, were trained to a moderate criterion of 7/10 correct trials and were then divided into two equal groups based on acquisition performance. One group received oral administration of DHEAS (1.5 mg/mouse/day) in a vehicle solution (0.0015% methyl salicylate) while the other group received the vehicle alone. DHEAS effects were assessed using a procedure in which delay intervals (0,20, and 240 s) were interposed between sample and comparison trials over the course of three test sessions. The group receiving DHEAS recorded significantly higher retention scores across 3 days of testing, particularly at the 120-s delay interval, indicating that DHEAS enhanced working memory in these aged animals. (C) 2001 Elsevier Science Inc. All rights reserved.