Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer
Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer
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DOI：
10.1016/j.biopha.2021.112343
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发表时间：
2021-12-01
影响因子：
7.5
通讯作者：
Du, Hongwu
中科院分区：
文献类型：
--
作者：
Hang, Zhongci;Lei, Tong;Du, Hongwu
越来越多的流行病学研究表明，阿尔茨海默病/帕金森病（AD/PD）的发病与癌症之间存在显著的反比关系，但其机制尚不清楚。考虑到肠道植物群可以将它们联系起来，我们试图从肠道植物群来解释这一现象。本文简要介绍了AD/PD、肿瘤与肠道植物群的关系，研究了肠道植物群的代谢产物或成分，以及肠道屏障和肠道激素在AD/PD和肿瘤中的作用。经过筛选，获得了部分能够同时参与这三种疾病发生过程的植物群，总结了AD/PD和各类癌症中特殊植物群的丰度变化，并根据植物群功能和丰度进行了分类，这反过来又创新地合理地解释了AD/从肠道植物群的角度看，PD与癌症在流行病学统计中表现出一定的拮抗作用。本综述还提出，从肠道植物群的角度来看待疾病之间的风险关系，可能为粪便微生物群移植（FMT）及相关疾病的治疗提供新的研究思路。
An increasing number of epidemiological studies have shown that there is a significant inverse relationship between the onset of Alzheimer's disease/Parkinson's disease (AD/PD) and cancer, but the mechanism is still unclear. Considering that intestinal flora can connect them, we tried to explain this phenomenon from the intestinal flora. This review briefly introduced the relationship among AD/PD, cancer, and intestinal flora, studied metabolites or components of the intestinal flora and the role of intestinal barriers and intestinal hormones in AD/PD and cancer. After screening, a part of the flora capable of participating in the occurrence processes of the three diseases at the same time was obtained, the abundance changes of the special flora in AD/PD and various types of cancers were summarized, and they were classified according to the flora function and abundance, which in turn innovatively and reasonably explained the fact that AD/PD and cancer showed certain antagonism in epidemiological statistics from the perspective of intestinal flora. This review also proposed that viewing the risk relationship between diseases from the perspective of intestinal flora may provide new research ideas for the treatment of fecal microbiota transplantation (FMT) and related diseases.