Rate of evolution and gene dispensability
Rate of evolution and gene dispensability
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DOI：
10.1038/421496b
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发表时间：
2003-01-30
期刊：
影响因子：
64.8
通讯作者：
Hurst, LD
中科院分区：
文献类型：
--
作者：
Pál, C;Papp, B;Hurst, LD
可有可无的基因是否比可有可无的基因进化得更快是一个有争议的问题。通过比较酵母和蠕虫基因，赫什和弗雷泽观察到了一种渐进的趋势，即较少的可有可无的基因(那些在被敲除后会降低酵母生长速度的基因)具有较低的蛋白质进化速度。在这里，我们使用更大的数据集重复他们的分析，没有发现任何证据表明可有可无可以解释蛋白质进化速度的差异。尽管赫什和弗雷泽提供了一个模型来说明为什么他们的结果是可以预期的，但我们的分析表明，他们的模型不能普遍适用，该模型假设没有替代是有利的。
Whether more dispensable genes evolve faster than less dispensable ones is a contentious issue,,. Comparing yeast and worm genes, Hirsh and Fraser observe a gradual tendency for less dispensable genes (those that reduce the growth rate of yeast when knocked out) to have lower rates of protein evolution. Here we repeat their analysis using larger data sets and find no evidence that dispensability explains the variation in rates of protein evolution. Although Hirsh and Fraser provide a model to show why their result is to be expected, our analysis suggests that their model, which assumes among other things that no substitution is advantageous, cannot be generally applied.