t(11;18)(q21;q21.1): A recurring translocation in lymphomas of mucosa‐associated lymphoid tissue (malt)?
t(11;18)(q21;q21.1): A recurring translocation in lymphomas of mucosa‐associated lymphoid tissue (malt)?
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t(11;18)(q21;q21.1)：粘膜相关淋巴组织（麦芽）淋巴瘤中的反复易位？
作者：
D. Horsman;R. Gascoyne;R. Coupland;R. Klasa
最近定义了一种来源于粘膜相关淋巴组织（MALT）的淋巴结恶性淋巴瘤的独特亚型。我们在一个胃MALT淋巴瘤患者中检测到获得性t（11;18）（q21;q21.1）。这种易位以前曾在另外两名结淋巴瘤患者中描述过。BCL 2癌基因位于带18q21.3，在滤泡性淋巴瘤中被t（14;18）（q32;q21）激活，在该病例中没有重排。这种新发现的t（11;18）可能是一种与MALT淋巴瘤特异性相关的复发性易位。位于11号和/或18号染色体断裂点的基因可能对这种类型的恶性淋巴瘤的发病机制至关重要。
A distinct subtype of extranodal malignant lymphoma derived from mucosa‐associated lymphoid tissues (MALT) has recently been defined. We have detected an acquired t(11;18)(q21;q21.1) in a patient with a MALT lymphoma of the stomach. This translocation has previously been described in two other patients with extranodal lymphoma. The BCL2 oncogene, which is located at band 18q21.3 and is activated by the t(14;18)(q32;q21) in follicular lymphoma, was not rearranged in this case. This newly identified t(11;18) may be a recurring translocation specifically associated with MALT lymphomas. Genes located at the breakpoint sites of chromosome 11 and/or chromosome 18 may be crucial to the pathogenesis of this type of malignant lymphoma.
单核细胞样 B 细胞淋巴瘤。
DOI：
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发表时间：
1986
期刊：
The American journal of pathology
影响因子：
--
作者：
Sheibani,K;Sohn,CC;Burke,JS;Winberg,CD;Wu,AM;Rappaport,H
通讯作者：
Rappaport,H
通过聚合酶链式反应和对滤泡性淋巴瘤中酶促扩增 DNA 的直接基因组测序来检测 bcl-2 小簇区域内的染色体易位 t(14;18)。
影响因子：
20.3
作者：
Ngan,BY;Nourse,J;Cleary,ML
通讯作者：
Cleary,ML