Finasteride in the treatment of men with androgenetic alopecia
Finasteride in the treatment of men with androgenetic alopecia
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DOI：
10.1016/s0190-9622(98)70007-6
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发表时间：
1998-10-01
影响因子：
13.8
通讯作者：
Gormley, GJ
中科院分区：
文献类型：
--
作者：
Kaufman, KD;Olsen, EA;Gormley, GJ
背景资料：雄激素性脱发（男性型脱发）是由雄激素依赖性头皮毛囊小型化引起的，头皮双氢睾酮（DHT）是一个促成因素。Finlavide是一种II型Sa-还原酶抑制剂，通过抑制睾酮向DHT的转化来降低血清和头皮DHT。目的：我们的目的是确定Finlavide治疗是否能改善男性脱发的临床症状。在两个为期一年的试验中，1553名男性（18 - 41岁）男性型脱发患者接受口服芬普胺1 mg/d或安慰剂，1215名男性继续进行第二年的盲法扩展研究。通过头皮毛发计数、患者和研究者评估以及专家小组对照片的审查来评估疗效。结果：在1年和2年时，通过所有评估技术，芬达治疗改善了头皮毛发（所有比较中，与安慰剂相比，P <0.001）。在脱发头顶的L英寸直径圆形区域（5.1 cm（2））测量，使用芬那普胺治疗后，观察到头发数量（基线= 876根头发）的临床显著增加（1年和2年时分别为107根和138根头发vs安慰剂; P <0.001）。安慰剂治疗导致进行性脱发。患者的自我评估表明，芬普胺治疗减缓了脱发，增加了头发生长，并改善了头发的外观。研究者评估和照片评估证实了这些改善。结论：在男性型脱发的男性中，在2年以上的临床试验中，finlutde 1 mg/d减缓了脱发的进展并增加了毛发生长。
Background: Androgenetic alopecia (male pattern hair loss) is caused by androgen-dependent miniaturization of scalp hair follicles, with scalp dihydrotestosterone (DHT) implicated as a contributing cause. Finasteride, an inhibitor of type II Sa-reductase, decreases serum and scalp DHT by inhibiting conversion of testosterone to DHT.Objective: Our purpose was to determine whether finasteride treatment leads to clinical improvement in men with male pattern hair loss.Methods: In two I-year trials, 1553 men (18 to 41 years of age) with male pattern hair loss received oral finasteride I mg/d or placebo, and 1215 men continued in blinded extension studies for a second year. Efficacy was evaluated by scalp hair counts, patient and investigator assessments, and review of photographs by an expert panel.Results: Finasteride treatment improved scalp hair by all evaluation techniques at 1 and 2 years (P < .001 vs placebo, all comparisons). Clinically significant increases in hair count (baseline = 876 hairs), measured in a L-inch diameter circular area (5.1 cm(2)) of balding vertex scalp, were observed with finasteride treatment (107 and 138 hairs vs placebo at 1 and 2 years, respectively; P < .001). Treatment with placebo resulted in progressive hair loss. Patients' self-assessment demonstrated that finasteride treatment slowed hair loss, increased hair growth, and improved appearance of hair. These improvements were corroborated by investigator assessments and assessments of photographs. Adverse effects were minimal.Conclusion: In men with male pattern hair loss, finasteride 1 mg/d slowed the progression of hair loss and increased hair growth in clinical trials over 2 years.