CHRONOBIOLOGY OF AGING - TEMPERATURE, SLEEP-WAKE RHYTHMS AND ENTRAINMENT
CHRONOBIOLOGY OF AGING - TEMPERATURE, SLEEP-WAKE RHYTHMS AND ENTRAINMENT
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DOI：
10.1016/0197-4580(82)90018-5
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发表时间：
1982-01-01
影响因子：
4.2
通讯作者：
ZIMMERMAN, JC
中科院分区：
文献类型：
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作者：
WEITZMAN, ED;MOLINE, ML;ZIMMERMAN, JC
对6名年轻人（23-30岁）和6名老年人（53-70岁）的正常男性进行了研究，他们生活在暂时而非社会孤立的条件下，时间为3至8周。在牵引和非牵引（自由奔跑）条件下，对这两个年龄组的睡眠-觉醒周期、睡眠阶段和直肠温度节律进行了比较测量。观察到老年人自由跑步时体温节律的周期和幅度有所减少。睡眠效率、总睡眠时间、REM（快速眼动）睡眠潜伏期、REM发作时长、睡眠最后2小时REM的百分比、睡眠中觉醒的时长和频率、终末觉醒潜伏期均与年龄相关，且依赖于带动。睡眠-觉醒周期、快速眼动末期觉醒和睡眠前3小时快速眼动的百分比与年龄无关，而是取决于被带动。睡眠阶段占总睡眠时间的百分比与年龄有关，但与娱乐无关；而睡眠潜伏期、快速眼动中期到快速眼动中期周期长度和睡眠时间占总时间的比例与年龄无关，也不依赖于夹带。个体时间生物学差异在老年组中表现突出。在非夹带状态下，部分受试者的睡眠-觉醒节律和体温节律的周期和相位关系发生了变化。
Studies were carried out on a group of 6 young(ages 23-30) and 6 older (aged 53-70) normal men who lived under conditions of temporal, but not social isolation, from 3- to 8-wk. During entrained and non-entrained (free-running) conditions, comparative measurements were made of sleep-wake cycles, sleep stages and rectal temperature rhythms for these 2 age groups. A reduction in the period and amplitude of the body temperature rhythms during free-running in the older group was observed. Sleep efficiency, total sleep time, REM [rapid eye movement] sleep latency, REM episode length, percent REM in the last 2 h of sleep, the length and frequency of arousals during sleep, and the terminal wake latency were all age related and dependent on entrainment. The period of the sleep-wake cycle, terminal awakenings from REM and percent REM in the first 3 h of sleep were not age related but were dependent on entrainment. Sleep stages as percents of total sleep time were age related but independent of entrainment; while sleep latency, mid-REM to mid-REM cycle length and the ratio of sleep to total time were neither age related nor dependent on entrainment. Individual chronobiological differences were prominent in the older group. Changes of period and of the phase relationship of sleep-wake and temperature rhythms occurred in several subjects during the non-entrained condition.