Spatiotemporal Distribution of β-Amyloid in Alzheimer Disease Is the Result of Heterogeneous Regional Carrying Capacities
Spatiotemporal Distribution of β-Amyloid in Alzheimer Disease Is the Result of Heterogeneous Regional Carrying Capacities
复制标题
DOI：
10.2967/jnumed.117.194720
复制
发表时间：
2018-05-01
影响因子：
9.3
通讯作者：
Gunn, Roger N.
中科院分区：
文献类型：
--
作者：
Whittington, Alex;Sharp, David J.;Gunn, Roger N.
β-淀粉样蛋白（A β）在脑中的积累是阿尔茨海默病（AD）的两个病理标志之一，并且已经在体外广泛研究了A β的空间分布。方法：我们将数学建模应用于A β体内PET成像数据，以研究AD中A β扩散的竞争理论。结果如下：我们的研究结果提供的证据表明，A β积累开始在所有的大脑区域同时，其时空分布是由于异质区域承载能力（区域最大可能浓度的A β）的聚集蛋白，而不是从种子区域的长期传播。结论：AD中A β的体内时空分布可以使用逻辑生长模型进行数学建模，其中A β携带能力在整个大脑中是异质的，但指数生长速率和半最大A β浓度的时间是恒定的。
beta-amyloid (A beta) accumulation in the brain is 1 of 2 pathologic hall-marks of Alzheimer disease (AD), and the spatial distribution of A beta has been studied extensively ex vivo. Methods: We applied mathematical modeling to A beta in vivo PET imaging data to investigate competing theories of A beta spread in AD. Results: Our results provided evidence that A beta accumulation starts in all brain regions simultaneously and that its spatiotemporal distribution is due to heterogeneous regional carrying capacities (regional maximum possible concentration of A beta) for the aggregated protein rather than to longer-term spreading from seed regions. Conclusion: The in vivo spatiotemporal distribution of A beta in AD can be mathematically modeled using a logistic growth model in which the A beta carrying capacity is heterogeneous across the brain but the exponential growth rate and time of half maximal A beta concentration are constant.