Side Effects of Leukotriene Receptor Antagonists in Asthmatic Children
Side Effects of Leukotriene Receptor Antagonists in Asthmatic Children
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DOI：
10.5812/ijp.3313
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发表时间：
2015-10-01
影响因子：
0.5
通讯作者：
Can, Demet
中科院分区：
文献类型：
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作者：
Erdem, Semiha Bahceci;Nacaroglu, Hikmet Tekin;Can, Demet
研究背景：白三烯受体拮抗剂（LTRA）是一种应用广泛的药物，已有十多年的历史。随着使用LTRAs的增加，我们的知识，就其副作用增加，以及.Objectives：我们的研究的目的是评估观察到的副作用LTRAs用于患者astma.Patients和方法：1024例患者治疗仅与LTRAs由于哮喘或早期喘息被列入研究为期五年。对这些患者中观察到的LTRAs副作用进行了回顾性研究。结果：1024例患者中，41例发生不良反应，男性占67.5%，女性占32.5%，平均年龄6.5岁。哮喘患病率为63.41%，36.58%的患者有早期喘息。确定患者的性别、年龄和诊断（早期喘息或哮喘）对副作用的出现无效。出现副作用的平均时间是第一个月。据观察，多动是最常见的精神科副作用，腹痛是非精神科副作用。结论：LTRAs的副作用是常见的儿童。因此，必须在治疗开始时告知患者，并在一定时间间隔内对其进行评估。
Background: Leukotriene receptor antagonists (LTRAs) are drugs which have been widely used more than ten years. As the use of LTRAs increases, our knowledge with respect to their side effects increases as well.Objectives: The objective of our study was to evaluat the observed side effects of LTRAs used in patients with astma.Patients and Methods: 1024 patients treated only with LTRAs owing to asthma or early wheezing were included in the study for a five-year period. The observed side effects of LTRAs in these patients were retrospectively investigated. The side effects were divided into two parts as psychiatric and non-psychiatric.Results: Among the 1024 cases included in the study, 67.5% of the patients out of 41 with side effects were male, 32.5% were female and the average age was 6.5 years. The rate of patients with asthma was 63.41% and 36.58% of the patients had early wheezing. It was determined that sex, age and diagnosis (early wheezing or asthma) of the patients were ineffective in the emergence of side effects. The average period for the emergence of side effects was the first month. It was observed that hyperactivity was the most frequently observed psychiatric side effect and that abdominal pain was the non-psychiatric side effect.Conclusions: The side effects of LTRAs were common in children. Therefore, patients must be informed at the beginning of the treatment and they must be evaluated at certain intervals.