The association fo obesity, cytokine levels, and depressive symptoms with diverse measures of fatigue in healthy subjects
The association fo obesity, cytokine levels, and depressive symptoms with diverse measures of fatigue in healthy subjects
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DOI：
10.1001/archinte.165.8.910
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发表时间：
2005-04-25
影响因子：
--
通讯作者：
Dimsdale, JE
中科院分区：
文献类型：
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作者：
Lim, WJ;Hong, S;Dimsdale, JE
背景：疲劳是一种常见的症状，即使在健康的个体中也是如此，但很少。我理解。我们研究了健康受试者中肥胖、抑郁症状、细胞因子水平和多维疲劳症状之间的关系。此外，我们还研究了肥胖是否会导致疲劳，如果是的话，哪种疲劳症状似乎与肥胖有关。方法：70名平均年龄36.0岁、体重小于等于理想体重170%的健康受试者（女性36名，男性34名）参加研究。研究人员测量了参与者的身高、体重、颈围、腰臀比、体脂率、血浆白细胞介素6和可溶性细胞间粘附分子I的浓度。研究人员用夜间多导睡眠图监测他们的睡眠，并让受试者完成多维疲劳症状量表（测量5个疲劳领域）和表皮学研究中心抑郁量表的简短形式。结果：用体重指数（体重以公斤为单位除以身高以米为单位的平方）和体脂百分比来衡量的肥胖与全身疲劳有关。抑郁得分与疲劳各分量表显著相关；与情绪疲劳的相关性最高。肥胖对身体疲劳的影响是显著的，即使在控制抑郁之后也是如此。一般来说，白细胞介素6和可溶性细胞间粘附分子-1水平与疲劳测量无关。结论：肥胖、细胞因子浓度和抑郁症状解释了多维疲劳症状量表测量的不同维度的疲劳。在控制抑郁症状和循环白细胞介素6和可溶性细胞间粘附分子-1水平后，肥胖占身体疲劳的重要部分。
Background: Fatigue is a common symptom, even among healthy individuals, but little is. understood about it. We examined the associations among adiposity, depressive Symptoms, cytokine levels, and multidimensional fatigue symptoms in otherwise healthy subjects. Furthermore, we examined whether obesity would account for a significant portion of fatigue and, if so, what kind of fatigue complaints appear to be related to obesity.Methods: Seventy healthy subjects (36 women and 34 men) with an average age of 36.0 years and at less than or equal to 170% of ideal body weight participated in the study. Participants had their height, weight, neck circumference, ratio of the waist to hip circumference, percentage of body fat, and plasma interleukin 6 and soluble intercellular adhesion molecule I concentrations measured. Their sleep was monitored with an overnight polysomnogram, and subjects completed the short form of the Multidimensional Fatigue Symptom inventory, which measures 5 domains of fatigue, and the Center for Epidermologic Studies-Depression Scale.Results: Obesity, as measured by body mass index (calculated as weight in kilograms divided by the square of height in meters) and percentage of body fat, was associated with general fatigue. Depression scores were significantly related to all subscales of fatigue; the highest correlation was shown with emotional fatigue. The effect of obesity on physical fatigue was significant, even after controlling for depression. In general, interleukin 6 and soluble intercellular adhesion molecule-1 levels were unrelated to measures of fatigue.Conclusions: Obesity, cytokine concentrations, and depressive symptoms explained different dimensions of fatigue as measured by the short form of the Multidimensional Fatigue Symptom Inventory. Obesity accounted for a significant portion of physical fatigue after controlling for depressive symptoms and circulating levels of interleukin 6 and soluble intercellular adhesion molecule-1.