Antagonistic effect of bacteriocin against urinary catheter associated Pseudomonas aeruginosa biofilm.
Antagonistic effect of bacteriocin against urinary catheter associated Pseudomonas aeruginosa biofilm.
复制标题
细菌素对尿道导管相关的假单胞菌生物膜的拮抗作用。
DOI：
10.4297/najms.2011.3367
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发表时间：
2011-08
期刊：
影响因子：
--
通讯作者：
Ghafil JA
中科院分区：
文献类型：
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作者：
Al-Mathkhury HJ;Ali AS;Ghafil JA
铜绿假单胞菌是一种革兰氏阴性机会性细菌，会导致多种感染，通常会在这些设备上定植并形成生物膜。生物膜中的细菌对抗生素的耐药性比浮游状态下的相同细菌高出 1,000 倍。从导管相关尿路感染中分离出总共 10 株铜绿假单胞菌。虽然羧苄青霉素是最有效的抗生素，但所有分离株都产生了多重耐药性。粗制和纯化的细菌素均对高度耐药的铜绿假单胞菌 P7 分离株的浮游生物和生物膜显示出显着的抑制活性。从局部分离的嗜酸乳杆菌中提取的细菌素具有抗铜绿假单胞菌生物膜活性，经过充分的体内实验后也可用作治疗剂。
Pseudomonas aeruginosa is a gram negative opportunistic bacteria causes several infections commonly colonize these devices and developing biofilms. Bacteria in biofilm can be up to 1,000 times more resistant to antibiotics than the same bacteria circulating in a planktonic state. A total of 10 isolates of Pseudomonas aeruginosa were isolated from catheter associated urinary tract infections. While carbenicillin was the most effective antibiotic, all isolates developed multidrug resistant. Both crude and purified bacteriocin showed marked inhibition activity against planktonic and biofilm of the highly resistant isolate P. aeruginosa P7. Bacteriocin extracted from a locally isolated L. acidophilus has an anti P. aeruginosa biofilm activity also it can be used as a therapeutic agent after adequate in vivo experimentation.