In vivo Functions of Natural Killer Cells
In vivo Functions of Natural Killer Cells
复制标题
自然杀伤细胞的体内功能
DOI：
10.1159/000154981
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
S. Pollack
中科院分区：
文献类型：
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作者：
S. Pollack
本文综述了最近的实验中，自然杀伤（NK）室已被直接操纵在体内被动转移的NK富集的细胞群体或NK细胞的选择耗尽。这些数据为NK细胞在体内的作用提供了直接证据。很明显，由于体内相互作用的复杂性，即使这些实验也具有固有的局限性。然而，总的来说，这些数据为NK细胞的体内活性及其生物学重要性提供了令人信服的理由。大多数实验都是在老鼠身上进行的。尽管NK细胞之间存在异质性，但这些研究主要涉及经典NK细胞，其定义为非粘附的并且携带NK相关抗原NK-1和无唾液酸-GM 1的骨髓来源的非B（IG/sup -/）、非T（Lyt 1/sup -/2/sup -/）淋巴细胞。一个自然的模型，已被利用来研究NK细胞在完整的主机进行了讨论。
This review focuses on recent experiments in which the natural killed (NK) compartment has been directly manipulated in vivo either by passive transfer of NK-enriched cell populations or by selection depletion of NK cells. These data have provided direct evidence for the role of NK cells in vivo. It is evident that even these experiments have inherent limitations due to the complexity of in vivo interactions. In the aggregate, however, these data build a compelling case for the in vivo activity of NK cells and for their biologic importance. Most of the experiments were carried out in mice. Although there is heterogeneity among NK cells, these studies deal mainly with classical NK cells defined as bone marrow-derived, non-B (Ig/sup -/), non-T (Lyt 1/sup -/2/sup -/) lymphocytes that are nonadherent and bear the NK-associated antigens NK-1 and asialo-GMl. A natural model which has been exploited to study NK cells in the intact host is also discussed.