Respiratory Function in Healthy Late Preterm Infants Delivered at 33-36 Weeks of Gestation
Respiratory Function in Healthy Late Preterm Infants Delivered at 33-36 Weeks of Gestation
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DOI：
10.1016/j.jpeds.2012.09.042
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发表时间：
2013-03-01
影响因子：
5.1
通讯作者：
Thuan Nguyen
中科院分区：
文献类型：
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作者：
McEvoy, Cindy;Venigalla, Sridevi;Thuan Nguyen
目的比较肺功能测试，包括呼吸顺应性（Crs）和时间峰潮气呼气流量呼气时间（TPTEF：TE）在足月校正年龄在33-36周出生的健康婴儿与足月分娩的健康婴儿。研究设计我们进行了一项前瞻性队列研究的晚期早产儿出生在33-36周无临床呼吸系统疾病（0.21分数的吸入氧气），并在足月校正年龄进行了研究。对照组是在种族和性别上与早产儿相匹配的足月儿，并在分娩后72小时内进行研究。采用单次呼吸阻断技术测定Crs。最少收集50个流量-体积循环，以估计TPTEF：TE。结果晚期早产儿（n = 31;平均胎龄34.1周，出生体重2150克）和31名足月儿进行了研究，在长期校正年龄。与足月儿相比，晚期早产儿的Crs降低（1.14 vs 1.32 mL/cm H2O/kg; P <0.02），TPTEF：TE降低（0.308 vs 0.423; P <0.01）。晚期早产儿的呼吸阻力也增加（0.064 vs 0.043 cm H2O/mL/s; P <0.01）。（J Pediatr 2013;162：464-9）。
Objective To compare pulmonary function testing including respiratory compliance (Crs) and time to peak tidal expiratory flow to expiratory time (TPTEF:TE) at term corrected age in healthy infants born at 33-36 weeks of gestation versus healthy infants delivered at term.Study design We performed a prospective cohort study of late preterm infants born at 33-36 weeks without clinical respiratory disease (0.21 fraction of inspired oxygen) and studied at term corrected age. The comparison group was term infants matched for race and sex to the preterm infants and studied within 72 hours of delivery. Crs was measured with the single breath occlusion technique. A minimum of 50 flow-volume loops were collected to estimate TPTEF: TE.Results Late preterm infants (n = 31; mean gestational age 34.1 weeks, birth weight 2150 g) and 31 term infants were studied at term corrected age. The late preterm infants had decreased Crs (1.14 vs 1.32 mL/cm H2O/kg; P < .02) and decreased TPTEF: TE (0.308 vs 0.423; P < .01) when compared with the term infants. Late preterm infants also had an increased respiratory resistance (0.064 vs 0.043 cm H2O/mL/s; P < .01).Conclusions Healthy late preterm infants (33-36 weeks of gestation) studied at term corrected age have altered pulmonary function when compared with healthy term infants. (J Pediatr 2013;162:464-9).