The combined effects of dietary protein and fat on 7,12-dimethylbenz(a)anthracene-induced breast cancer in rats.
The combined effects of dietary protein and fat on 7,12-dimethylbenz(a)anthracene-induced breast cancer in rats.
复制标题
膳食蛋白质和脂肪对7,12-二甲基苯并(a)蒽诱发的大鼠乳腺癌的综合影响。
DOI：
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复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
W. Visek
中科院分区：
文献类型：
--
作者：
S. Clinton;P. Imrey;J. Alster;J. Simon;C. R. Truex;W. Visek
进行3 X 3析因实验，研究蛋白质含量（来自酪蛋白的8、16、32%千卡热量）和脂肪含量（来自玉米油的12、24、48%千卡热量）如何相互作用影响7，12-二甲基苯并（a）蒽（DMBA）诱导的大鼠乳腺癌发生。将40只断奶Sprague-Dawley大鼠随机分配至9种饲料中的每一种。4周后，每只大鼠通过胃插管接受DMBA（20 mg/kg）。没有观察到蛋白质和脂肪对肿瘤发生率的显著统计学相互作用。增加饮食中的玉米油增加了具有可触及肿瘤的大鼠的百分比。喂食含有12、24和48%千卡玉米油的饲料的大鼠在尸检时显示出35、49和70%的肿瘤患病率，每个脂肪水平的肿瘤总数分别为65、81和182。膳食脂肪浓度每增加一倍，大鼠患肿瘤的几率就增加一倍。多发性肿瘤在玉米油摄入量最高的人群中更常见。当脂肪千卡从24%增加到48%时，在患有一个肿瘤的大鼠中发现第二个肿瘤的几率增加了7.5倍，而当脂肪千卡从12%增加到24%时，则减少了三分之一。膳食玉米油显着增加腺癌和腺瘤的患病率，但不是纤维腺瘤。膳食蛋白质对肿瘤患病率没有显着影响。然而，在喂食16%千卡的大鼠中，肿瘤触诊，因为蛋白质比喂食低蛋白或高蛋白饮食的大鼠更频繁地消退。多元逻辑回归结果表明，除了对膳食玉米油的反应外，在随意进食量更大的大鼠中，肿瘤发生增加。这一结论得到了使用直接利率调整和平均部分关联检验的再分析的支持。
A 3 X 3 factorial experiment was conducted to examine how protein content (8, 16, 32% of kilocalories from casein) and fat content (12, 24, 48% of kilocalories from corn oil) interact to influence 7,12-dimethylbenz(a)anthracene (DMBA)-induced breast carcinogenesis in rats. Forty weanling Sprague-Dawley rats were assigned to each of 9 diets fed ad libitum. After 4 weeks each rat received DMBA (20 mg/kg) via gastric intubation. No substantial statistical interactions of protein and fat were observed on tumor incidence. Increasing dietary corn oil increased the percentage of rats with palpable tumors. Rats fed diets containing 12, 24 and 48% of kilocalories from corn oil showed 35, 49 and 70% tumor prevalence at necropsy, and the total number of tumors per fat level was 65, 81 and 182, respectively. Each doubling of dietary fat concentration approximately doubled the odds of a rat developing a tumor. Multiple tumors were more common with the highest corn oil intake. The odds of finding a second tumor in rats with one tumor increased by a factor of 7.5 when fat kilocalories were increased from 24 to 48% compared to a decrease of one-third when fat kilocalories were increased from 12 to 24%. Dietary corn oil significantly increased the prevalence of adenocarcinomas and adenomas but not fibroadenomas. Dietary protein did not significantly affect tumor prevalence. However, tumors palpated in rats fed 16% of kilocalories as protein regressed more frequently than in rats fed low or high protein diets. Multiple logistic-regression results indicate that, in addition to the response to dietary corn oil, tumorigenesis was increased in rats with greater ad libitum food consumption. This conclusion is supported by reanalysis that used direct rate adjustment and average partial association tests.
影响因子：
11.2
作者：
Ian J. Tinsley;John A. Schmitz;Donald A. Pierce
通讯作者：
Ian J. Tinsley;John A. Schmitz;Donald A. Pierce
7,12-二甲基苯并[a]蒽诱发的乳腺肿瘤中的血清雌激素和雌激素反应性受膳食脂肪的影响。
DOI：
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发表时间：
1981
期刊：
Journal of the National Cancer Institute
影响因子：
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作者：
Ip,C;Ip,MM
通讯作者：
Ip,MM