Effect of Probiotic Bacteria on Oral Candida in Frail Elderly
Effect of Probiotic Bacteria on Oral Candida in Frail Elderly
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DOI：
10.1177/0022034515595950
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发表时间：
2015-09-01
影响因子：
7.6
通讯作者：
Twetman, S.
中科院分区：
文献类型：
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作者：
Kraft-Bodi, E.;Jorgensen, M. R.;Twetman, S.
本研究的目的是调查每日摄入益生菌乳酸杆菌对生活在疗养院的体弱老年患者口腔念珠菌的患病率和计数的影响。该研究采用双盲、随机、安慰剂对照设计，有2个平行组。研究组包括215名老年人（范围60至102岁），他们在知情同意后入组。在基线检查和随机分组后，受试者每天两次（早晨和晚上）服用1粒含有2株益生菌罗伊氏乳杆菌（DSM 17938和ATCC PTA 5289）的锭剂或安慰剂。干预期为12周，在基线和随访时收集唾液和牙菌斑样本。主要终点是椅旁试验评估的高念珠菌计数的患病率。次要终点是牙菌斑和牙龈炎症的水平。各组在基线时平衡。随访的脱落率为19%。在益生菌组中，高念珠菌计数的患病率在统计学上显著降低，而在安慰剂组中没有，并且在唾液和菌斑中的差异具有统计学意义（P < 0.05）。两组间龈上菌斑或探诊出血的水平无显著差异。因此，每日使用益生菌含片可降低体弱老年疗养院居民口腔念珠菌计数高的患病率（ClinicalTrials.gov NCT 02391532）。
The aim of this study was to investigate the effect of a daily intake of probiotic lactobacilli on the prevalence and counts of oral Candida in frail elderly patients living in nursing homes. The study had a double-blind randomized placebo-controlled design with 2 parallel arms. The study group consisted of 215 older adults (range, 60 to 102 y) who were enrolled after informed consent. After baseline examination and randomization, the subjects were given 1 lozenge containing 2 strains of the probiotic bacterium Lactobacillus reuteri (DSM 17938 and ATCC PTA 5289) or placebo twice daily (morning and evening). The intervention period was 12 wk, and saliva and plaque samples were collected at baseline and follow-up. The primary end point was prevalence of high Candida counts assessed from chairside tests. Secondary end points were levels of dental plaque and gingival inflammation. The groups were balanced at baseline. The attrition rate to follow-up was 19%. There was a statistically significant reduction in the prevalence of high Candida counts in the probiotic group but not in the placebo group, and the difference was statistically significant in both saliva and plaque (P < 0.05). No significant differences between the groups were noted concerning the levels of supragingival plaque or bleeding on probing. Thus, daily use of probiotic lozenges may reduce the prevalence of high oral Candida counts in frail elderly nursing homes residents (ClinicalTrials.gov NCT02391532).