Performance Evaluation of the LabPET APD-Based Digital PET Scanner
Performance Evaluation of the LabPET APD-Based Digital PET Scanner
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DOI：
10.1109/tns.2008.2010257
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发表时间：
2009-02-01
影响因子：
1.8
通讯作者：
Lecomte, Roger
中科院分区：
文献类型：
--
作者：
Bergeron, Melanie;Cadorette, Jules;Lecomte, Roger
LabPET（TM）是一种基于雪崩光电二极管（APD）的全数字PET扫描仪，设计用于小动物的最先进分子和基因组成像。评估了两个版本的扫描仪，轴向视野为3.75（LabPET 4）和7.5 cm（LabPET 8）。探测器由2 x 2 x 12/14 mm（3）LYSO和LGSO晶体制成，并通过APD读取。经过晶体数字鉴定，LYSO的平均能量分辨率为24 ± 6%，LGSO的平均能量分辨率为256%。扫描仪的整体时间分辨率为6.6 ns的LYSO/LYSO和10.7 ns的LGSO/LGSO符合后粗定时对准。FBP重建的切向/径向分辨率在FOV中心为1.3/1.4 mm FWHM（2.5/2.4 mm FWTM），在中心4 cm直径FOV内保持低于2.1 mm FWHM（3.6 mm FWTM）。微分辨率体模的MLEM重建提供了1.0 mm斑点的清晰分离。在250-650 keV的能量窗口下，LabPET 4的灵敏度为1.1%，LabPET 8为2.1%。扫描仪的成像能力证明了在体内的大鼠和小鼠的图像。
The LabPET (TM) is a fully digital avalanche photodiode (APD) based PET scanner designed for state-of-the-art molecular and genomic imaging of small animals. Two versions of the scanner were evaluated, having 3.75 (LabPET4) and 7.5 cm axial FOV (LabPET8). The detectors are made of 2 x 2 x 12/14 mm(3) LYSO and LGSO crystals assembled in phoswich pairs read out by an APD. After digital crystal identification, the average energy resolution is 24 +/- 6% for LYSO and 25 6% for LGSO. The scanner's overall timing resolution is 6.6 ns for LYSO/LYSO and 10.7 ns for LGSO/LGSO coincidences after coarse timing alignment. The FBP reconstructed tangential/radial resolution is 1.3/1.4 mm FWHM (2.5/2.4 mm FWTM) at the FOV center and remains below 2.1 mm FWHM (3.6 mm FWTM) within the central 4-cm diameter FOV. MLEM reconstruction of a micro resolution phantom provided clear separation of the 1.0 mm spots. With an energy window of 250-650 keV, the sensitivity is 1.1% for LabPET4 and 2.1% for LabPET8. The imaging capabilities of the scanner are demonstrated with in vivo images of rats and mice.