PRC1 is taking the lead in PcG repression
PRC1 is taking the lead in PcG repression
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DOI：
10.1111/tpj.12818
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发表时间：
2015-07-01
期刊：
影响因子：
7.2
通讯作者：
Calonje, Myriam
中科院分区：
文献类型：
--
作者：
Merini, Wiam;Calonje, Myriam
多梳族蛋白（Polycomb group，PcG）是植物基因阻遏的主要表观遗传机制。长期以来，PcG机制被认为遵循PcG阻遏复合物（PRCs）向靶基因的分级募集，其中PRC2的结合和H3赖氨酸27三甲基标记的掺入导致PRC1的募集，PRC1进而介导H2A单泛素化。然而，最近的研究已经把这个模型颠倒过来，表明PRC1活性可能是PRC2招募和H3K27me3标记所必需的。在这里，我们回顾了目前的知识，植物PRC1的组成和阻遏机制，以及它在植物发育过程中的作用。
Polycomb group (PcG) proteins constitute a major epigenetic mechanism for gene repression throughout the plant life. For a long time, the PcG mechanism has been proposed to follow a hierarchical recruitment of PcG repressive complexes (PRCs) to target genes in which the binding of PRC2 and the incorporation of H3 lysine 27 trimethyl marks led to recruitment of PRC1, which in turn mediated H2A monoubiquitination. However, recent studies have turned this model upside-down by showing that PRC1 activity can be required for PRC2 recruitment and H3K27me3 marking. Here, we review the current knowledge on plant PRC1 composition and mechanisms of repression, as well as its role during plant development.