TRIMMED SPEARMAN-KARBER METHOD FOR ESTIMATING MEDIAN LETHAL CONCENTRATIONS IN TOXICITY BIOASSAYS
TRIMMED SPEARMAN-KARBER METHOD FOR ESTIMATING MEDIAN LETHAL CONCENTRATIONS IN TOXICITY BIOASSAYS
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DOI：
10.1021/es60130a004
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发表时间：
1977-01-01
影响因子：
11.4
通讯作者：
THURSTON, RV
中科院分区：
文献类型：
--
作者：
HAMILTON, MA;RUSSO, RC;THURSTON, RV
讨论了几种处理毒性试验数据以确定半数致死浓度（LC_（50））的方法。目前广泛使用的概率单位法和对数单位法都存在一定的不足，因此，本文提出了一种新的计算方法--修剪Spearman-Karber法。给出了实际和假设的生物测定试验数据的例子，并比较了这3种方法处理这些数据的能力。修剪Spearman-Karber方法不受probit和logit模型问题的影响，具有良好的统计特性，易于使用，推荐用于准确和精确计算LC 50值及其95%置信区间终点。
Several methods for treatment of data from toxicity tests to determine the median lethal concentration (LC50) are discussed. The probit and logit models widely used for these calculations have deficiencies; therefore, a calculational method, named the trimmed Spearman-Karber method, is developed. Examples of actual and hypothetical bioassay test data are given, and comparisons are made of the abilities of these 3 methods to treat these data. The trimmed Spearman-Karber method is not subject to the problems of the probit and logit models, has good statistical properties, is easy to use, and is recommended for accurate and precise calculation of LC50 values and their 95% confidence interval end points.