Premedication medicines do not cause drug metabolic interaction with propofol using human liver microsomes in vitro
Premedication medicines do not cause drug metabolic interaction with propofol using human liver microsomes in vitro
复制标题
体外使用人肝微粒体，术前用药不会与丙泊酚引起药物代谢相互作用
DOI：
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发表时间：
2004
影响因子：
2.9
通讯作者：
K. Honda
中科院分区：
文献类型：
--
作者：
E. Tanaka;Y. Takano;S. Inomata;H. Toyooka;K. Honda
Objective: Propofol (2,6-diisopropylphenol) is widely used for anesthetic induction as well as for chronic sedation in intensive care units. In this study, we investigated the interaction between propofol and premedications, i.e., psychotropic and antianxiety agents (diazepam, midazolam), hypnotics (thiamylal), local anesthetics (lidocaine), depolarizing muscular relaxants (vecuronium), an antihypertensive (clonidine) and an H2-receptor antagonist (cimetidine) using human liver microsomes in vitro. Methods: The interaction effects between propofol and premedications were examined using human liver microsomal preparation in vitro. The concentration of propofol was determined by HPLC with UV detection. Results: The apparent Michaelis–Menten constant (Km) and the maximal velocity of total metabolic formation (Vmax) of propofol in human liver microsomes were 123 μM and 26.1 μmol/min per milligram of mg protein, respectively. Seven premedications (diazepam, midazolam, thiamylal, lidocaine, cimetidine, vecuronium, and clonidine) did not inhibit propofol metabolism in human liver microsomes at concentrations within the therapeutic range. Conclusions: These results showed no interactions between propofol and seven premedication drugs within the therapeutic range of propofol using human liver microsomes in vitro.
细胞色素 P4503A4 在阿芬太尼代谢多种途径中的催化作用。
DOI：
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发表时间：
1995
期刊：
Drug metabolism and disposition: the biological fate of chemicals
影响因子：
--
作者：
Labroo,RB;Thummel,KE;Kunze,KL;Podoll,T;Trager,WF;Kharasch,ED
通讯作者：
Kharasch,ED
影响因子：
3.9
作者：
Rae, JM;Soukhova, NV;Desta, Z
通讯作者：
Desta, Z