Simultaneous measurements of cerebral oxygenation changes during brain activation by near-infrared spectroscopy and functional magnetic resonance imaging in healthy young and elderly subjects
Simultaneous measurements of cerebral oxygenation changes during brain activation by near-infrared spectroscopy and functional magnetic resonance imaging in healthy young and elderly subjects
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DOI：
10.1002/hbm.10026
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发表时间：
2002-05-01
影响因子：
4.8
通讯作者：
Jansen, RWMM
中科院分区：
文献类型：
--
作者：
Mehagnoul-Schipper, DJ;van der Kallen, BFW;Jansen, RWMM
近红外光谱（NIRS）和功能磁共振成像（fMRI）都允许无创监测大脑皮层对各种刺激的氧合反应。为了在老年受试者中比较这些方法，并确定年龄对皮质氧合反应的影响，我们测定了6名健康年轻受试者左运动皮质脱氧血红蛋白浓度（[HHb]）的运动任务相关变化（年龄35 ± 9岁，平均值± SD）和5名健康老年受试者（年龄73 ± 3岁）同时通过NIRS和血氧水平依赖性（BOLD）fMRI。运动任务包括7个周期的20秒周期的对侧手指敲击，以尽可能快的速度与40秒的休息周期交替。7个循环的时间锁定平均值用于进一步分析。近红外光谱法测量了运动皮层上与任务相关的[HHb]减少，年轻受试者的最大变化为-0.83 +/- 0.38 μ mol/L（P < 0.01），老年受试者为-0.32 +/- 0.17 μ mol/L（P < 0.05）。BOLD-fMRI信号在NIRS研究的皮质体积上增加，年轻受试者的最大变化为2.11 ± 0.72%（P < 0.01），老年受试者的最大变化为1.75 ± 0.71%（P < 0.01）。NIRS和BOLD-fMRI测量结果在青年组（r =-0.70，r（2）= 0.48，P < 0.001）和老年组（r =-0.82，r（2）= 0.67，P < 0.001）具有良好的相关性。此外，NIRS测量结果显示，任务相关的脑氧合反应随年龄的增加而降低（P < 0.05），而fMRI测量结果显示，老年受试者的皮层激活区域较小（P < 0.05）。这些研究结果表明，近红外光谱和功能磁共振成像类似地评估皮质氧合变化的年轻受试者，也在老年受试者。此外，大脑皮层对大脑激活的氧合反应随着年龄的增长而改变。
Near infrared spectroscopy (NIRS) and functional magnetic resonance imaging (fMRI) both allow non-invasive monitoring of cerebral cortical oxygenation responses to various stimuli. To compare these methods in elderly subjects and to determine the effect of age on cortical oxygenation responses, we determined motor-task-related changes in deoxyhemoglobin concentration ([HHb]) over the left motor cortex in six healthy young subjects (age 35 +/- 9 years, mean +/- SD) and five healthy elderly subjects (age 73 +/- 3 years) by NIRS and blood-oxygen-level-dependent (BOLD) fMRI simultaneously. The motor-task consisted of seven cycles of 20-sec periods of contralateral finger-tapping at a rate as fast as possible alternated with 40-sec periods of rest. Time-locked averages over the seven cycles were used for further analysis. Task-related decreases in [HHb] over the motor cortex were measured by NIRS, with maximum changes of -0.83 +/- 0.38 mumol/L (P < 0.01) for the young and -0.32 +/- 0.17 mu mol/L (P < 0.05) for the elderly subjects. The BOLD-fMRI signal increased over the cortex volume under investigation with NIRS, with maximum changes of 2.11 +/- 0.72% (P < 0.01) for the young and 1.75 +/- 0.71% (P < 0.01) for the elderly subjects. NIRS and BOLD-fMRI measurements showed good correlation in the young (r = -0.70, r(2) = 0.48, P < 0.001) and elderly subjects (r = -0.82, r(2) = 0.67, P < 0.001). Additionally, NIRS measurements demonstrated age-dependent decreases in task-related cerebral oxygenation responses (P < 0.05), whereas fMRI measurements demonstrated smaller areas of cortical activation in the elderly subjects (P < 0.05). These findings demonstrate that NIRS and fMRI similarly assess cortical oxygenation changes in young subjects and also in elderly subjects. In addition, cortical oxygenation responses to brain activation alter with aging.