Neutrophil-to-lymphocyte ratio (NLR) distribution shows a better kinetic pattern than C-reactive protein distribution for the follow-up of early inflammation after total knee arthroplasty
Neutrophil-to-lymphocyte ratio (NLR) distribution shows a better kinetic pattern than C-reactive protein distribution for the follow-up of early inflammation after total knee arthroplasty
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DOI：
10.1007/s00167-015-3921-0
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发表时间：
2016-10-01
影响因子：
3.8
通讯作者：
Thienpont, E.
中科院分区：
文献类型：
--
作者：
Yombi, J. C.;Schwab, P. E.;Thienpont, E.
本研究旨在评价外周血嗜中性粒细胞/淋巴细胞比率（NLR）分布是否比C反应蛋白（CRP）分布具有更好的动力学模式，以评估全膝关节置换术（TKA）后早期炎症。在术前和术后第2、4、21和42天收集CRP和NLR。比较CRP和NLR的平均峰值和分布，第2、4、21和42天的平均CRP水平分别为163、161、9和7 mg/L。第2、4、21和42天的平均NLR水平分别为5、3.5、2.6和2.5。在第21天和第42天，20%（102/503）和21%（93/433）的患者未达到正常CRP水平。在第21天，有4.5%（23/503）的患者具有NLR > 5，并且有1%（5/503）的患者具有NLR > 10。在第42天，有5.5%（24/433）的患者的NLR > 5，0.7%（3/433）的患者的NLR > 10。NLR比CRP更快地恢复正常。它可能是一种更好的生物标志物，用于随访TKA. II术后炎症或早期感染。
This study aimed to assess whether the neutrophil-to-lymphocyte ratio (NLR) distribution could have a better kinetic pattern than C-reactive protein (CRP) distribution to evaluate early post-operative inflammation after total knee arthroplasty (TKA).A prospective study was performed on 587 patients. CRP and NLR were collected pre-operatively and at post-operative days 2, 4, 21 and 42. Mean peak values and distribution were compared between CRP and NLR.Mean CRP levels were 163, 161, 9 and 7 mg/L, respectively, at days 2, 4, 21 and 42. Mean NLR levels were 5, 3.5, 2.6 and 2.5, respectively, at days 2, 4, 21 and 42. At days 21 and 42, 20 % (102/503) and 21 % (93/433) of patients had not reached normal CRP levels. At day 21, there were 4.5 % (23/503) of patients with a NLR > 5 and 1 % (5/503) with an NLR > 10. At day 42, there were 5.5 % (24/433) of patients with an NLR > 5 and 0.7 % (3/433) with an NLR > 10.NLR has a faster normalization than CRP. It is potentially a better biomarker to follow post-operative inflammation or early infection after TKA.II.