Frequency and risk factors for meningioma in clinically healthy 75-year-old patients - Results of the transdanube ageing study (VITA)
Frequency and risk factors for meningioma in clinically healthy 75-year-old patients - Results of the transdanube ageing study (VITA)
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DOI：
10.1002/cncr.20088
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发表时间：
2004-03-15
期刊：
影响因子：
6.2
通讯作者：
Tragl, KH
中科院分区：
文献类型：
--
作者：
Krampla, W;Newrkla, S;Tragl, KH
背景临床上无症状的颅内肿瘤在特定人群中的患病率研究很少。众所周知，在高龄人群中，临床表现脑膜瘤的数量占实际病例数的比例很小。本研究的目的是确定老年无症状脑膜瘤患者的频率，并确定该人群中脑膜瘤的危险因素。2000年5月至2002年11月，来自维也纳特定地理区域的532名75岁的先证者接受了脑部磁共振成像扫描，并评估了占位性肿块的存在。所有先证者都进行了临床和神经学检查，以及由神经精神病学家。患者的病史（包括既往疾病、药物和生活方式）以及实验室报告均被仔细记录。收集的数据进行了相关性和相似性的主题与脑膜瘤被确定。在纳入试验的318名女性中观察到9例在调查之前未知的脑膜瘤（对应于75岁女性中临床无症状脑膜瘤的计算患病率为2800/100，000）。在男性中没有发现肿瘤。在任何受试者中均未观察到相关的临床变化或缺陷。除高龄和女性外，未发现其他公认或已知的危险因素。临床上静止的脑膜瘤在老年女性人口更常见，比被认为是迄今为止的情况。已知的和可影响的风险因素被认为是不太重要的年龄和性别。在决定对偶然发现的、临床上静止的脑膜瘤患者进行治疗时，应考虑到这种病变的高频率。(C)2004年美国癌症协会。
BACKGROUND. The prevalence of clinically silent intracranial tumors in specific populations is poorly researched. It is known that, in advanced age groups, number of clinically manifest meningiomas constitute a small proportion of the 3 actual number of cases. The goals of the current study were to determine the frequency of asymptomatic patients with meningioma in advanced age and to identify risk factors for meningiomas in this population.METHODS. Between May 2000 and November 2002, 532 probands from a specifically defined geographic area of Vienna who were age 75 years under-went a magnetic resonance imaging scan of the brain and were evaluated for the presence of a space-occupying mass. All probands were examined clinically and neurologically as well as by a neuropsychiatrist. The patients' medical histories were carefully documented with regard to previous diseases, medication, and lifestyle, as were their laboratory reports. The collected data were correlated and similarities among subjects with meningioma were determined.RESULTS. Nine meningiomas that were unknown until the time of investigation were observed among the 318 women included in the trial (corresponding to a calculated prevalence of 2800/100,000 clinically silent meningiomas in 75-year-old women). No tumors were found among men. Associated clinical changes or deficits were not observed in any subject. Apart from advanced age and female gender, no other accepted or well known risk factors were observed in the tumor patients.CONCLUSIONS. Clinically quiescent meningiomas in the elderly female population were more common than was believed to be the case to date. Known and influenceable risk factors were found to be less important than age and gender. The high frequency of this lesion should be considered when deciding on the treatment of patients with incidentally discovered, clinically quiescent meningiomas. (C) 2004 American Cancer Society.