THE ROLE OF THE FETUS IN THE WATER EXCHANGE OF THE AMNIOTIC FLUID OF NORMAL AND HYDRAMNIOTIC PATIENTS
THE ROLE OF THE FETUS IN THE WATER EXCHANGE OF THE AMNIOTIC FLUID OF NORMAL AND HYDRAMNIOTIC PATIENTS
复制标题
胎儿在正常和潮水患者羊水水交换中的作用
DOI：
10.1172/jci103880
复制
发表时间：
1959
影响因子：
6.2
通讯作者：
J. Lind
中科院分区：
文献类型：
--
作者：
D. L. Hutchinson;M. Gray;A. A. Plentl;Hermogenes Alvares;R. Caldeyro;B. Kaplan;J. Lind
在先前关于妊娠猴交换机制的报告（1）中，已经提出证据表明母体生物体和妊娠产物之间的水交换可以用由三个主要隔室组成的动力学模型来表示，所有隔室都相互交换。这三个隔室被定义为：1）羊水，2）母体，和3）胎儿体内的水。可以证明，将氢示踪剂引入胎儿或羊水中会产生可预测形状的保留曲线，并且当羊水用作主要隔室时，可以合理准确地计算水的转移速率。因此，应该有可能设计出一些方法来计算人类的转移率，并研究胎儿在羊水和母体之间的水交换中所起的作用。为了计算转移速率，有必要知道示踪剂浓度的变化作为每个隔室的时间函数。对孕妇的连续测量仅限于两个可接近的部分：母亲和羊水。此外，胎儿或脐带血的单一样本可以在分娩时获得。在这些条件下，有两种可能的方法可以从可用数据计算胎儿隔室的时间-活动曲线。第一个是基于
In a preceding report on exchange mechanisms in pregnant monkeys (1), evidence has been presented that the water exchange between the maternal organism and the products of gestation can be represented by a kinetic model composed of three major compartments, all of which exchange with each other. The three compartments are defined as: 1) the amniotic fluid, 2) the maternal, and 3) the fetal body water. It could be shown that the introduction of a hydrogen tracer into fetus or amniotic fluid results in retention curves of predictable shape and that transfer rates for water can be calculated with reasonable accuracy when the amniotic fluid was used as the primary compartment. It should therefore be possible to devise methods whereby the transfer rates for the human could be calculated and to study the role which the fetus plays in the exchange of water between the amniotic fluid and the mother. For the calculation of transfer rates it is necessary to know the change in concentration of tracer as a function of time for each compartment. Continuous measurements on pregnant women are limited to the two accessible compartments: mother and amniotic fluid. In addition, a single sample of fetal or cord blood can be obtained at the time of delivery. Under these conditions there are two possible ways in which a time-activity curve for the fetal compartment can be calculated from available data. The first is based upon the