Prevalence of the HOXB13 G84E prostate cancer risk allele in men treated with radical prostatectomy.
Prevalence of the HOXB13 G84E prostate cancer risk allele in men treated with radical prostatectomy.
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DOI：
10.1111/bju.12522
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发表时间：
2014-05
影响因子：
4.5
通讯作者：
Cooney KA
中科院分区：
文献类型：
--
作者：
Beebe-Dimmer JL;Isaacs WB;Zuhlke KA;Yee C;Walsh PC;Isaacs SD;Johnson AM;Ewing CE;Humphreys EB;Chowdhury WH;Montie JE;Cooney KA
To determine the prevalence and clinical correlates of the G84E mutation in the homeobox transcription factor (or HOXB13) gene using DNA samples from 9,559 men with prostate cancer undergoing radical prostatectomy. DNA samples from men treated with radical prostatectomy at the University of Michigan and John Hopkins University were genotyped for G84E and confirmed by Sanger sequencing. The frequency and distribution of this allele was determined according to specific patient characteristics (family history, age at diagnosis, pathologic Gleason grade and stage). 128 of 9,559 patients were heterozygous carriers of G84E (1.3%). Patients who possessed the variant were more likely to have a family history of prostate cancer (46.0% vs. 35.4% p=0.006). G84E carriers were also more likely diagnosed at a younger age compared to non-carriers (55.2 years vs. 58.1 years; p<0.0001). No difference in the proportion of patients diagnosed with high-grade or advanced stage tumors by carrier status was observed. In our study, carriers of the rare G84E variant in HOXB13 were both younger at the time of diagnosis and more likely to have a family history of prostate cancer compared to homozygotes for the wild-type allele. No significant differences in allele frequency were detected according to select clinical characteristics of prostate cancer. Further investigation is required to evaluate the role of HOXB13 in prostate carcinogenesis.
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影响因子：
2.8
作者：
Stott-Miller, Marni;Karyadi, Danielle M.;Smith, Tiffany;Kwon, Erika M.;Kolb, Suzanne;Stanford, Janet L.;Ostrander, Elaine A.
通讯作者：
Ostrander, Elaine A.
DOI：
10.1158/1055-9965.epi-12-0495
发表时间：
2012-08
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Breyer JP;Avritt TG;McReynolds KM;Dupont WD;Smith JR
通讯作者：
Smith JR
影响因子：
4.8
作者：
Huang, Liwei;Pu, Yongbing;Prins, Gail S.
通讯作者：
Prins, Gail S.
DOI：
10.1056/nejmoa1110000
发表时间：
2012-01-12
期刊：
The New England journal of medicine
影响因子：
--
作者：
Ewing CM;Ray AM;Lange EM;Zuhlke KA;Robbins CM;Tembe WD;Wiley KE;Isaacs SD;Johng D;Wang Y;Bizon C;Yan G;Gielzak M;Partin AW;Shanmugam V;Izatt T;Sinari S;Craig DW;Zheng SL;Walsh PC;Montie JE;Xu J;Carpten JD;Isaacs WB;Cooney KA
通讯作者：
Cooney KA
影响因子：
4.7
作者：
Chen, Zhuo;Greenwood, Celia;Xu, Jianfeng
通讯作者：
Xu, Jianfeng