Identifying Correlations between Chromosomal Proximity of Genes and Distance of Their Products in Protein-Protein Interaction Networks of Yeast
Identifying Correlations between Chromosomal Proximity of Genes and Distance of Their Products in Protein-Protein Interaction Networks of Yeast
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DOI：
10.1371/journal.pone.0057707
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发表时间：
2013-03-06
期刊：
影响因子：
3.7
通讯作者：
Paci, Paola
中科院分区：
文献类型：
--
作者：
Santoni, Daniele;Castiglione, Filippo;Paci, Paola
在本文中，我们提供了染色体基因位点与对应于所考虑的基因组的蛋白质-蛋白质相互作用网络的拓扑特性之间关系的证据。具体而言，对于酿酒酵母基因组的每个染色体，分析了染色体内基因间距离的分布，发现与蛋白质-蛋白质相互作用网络的相应蛋白质之间的距离呈正相关。为了研究这种关系，我们使用了基于非参数统计和信息论的概念。我们提供的统计证据表明，如果两个基因位置接近，那么它们的蛋白质产物很可能位于蛋白质-蛋白质相互作用网络中，或者换句话说，它们参与相同的生物过程。
In this article we present evidence for a relationship between chromosome gene loci and the topological properties of the protein-protein interaction network corresponding to the set of genes under consideration. Specifically, for each chromosome of the Saccharomyces cerevisiae genome, the distribution of the intra-chromosome inter-gene distances was analyzed and a positive correlation with the distance among the corresponding proteins of the protein-protein interaction network was found. In order to study this relationship we used concepts based on non-parametric statistics and information theory. We provide statistical evidence that if two genes are closely located, then it is likely that their protein products are closely located in the protein-protein interaction network, or in other words, that they are involved in the same biological process.