Juvenile rhesus monkeys have lower type 2 cytokine responses than adults after primary infection with Schistosoma mansoni
Juvenile rhesus monkeys have lower type 2 cytokine responses than adults after primary infection with Schistosoma mansoni
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DOI：
10.1086/368130
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发表时间：
2003-03-15
影响因子：
6.4
通讯作者：
Dunne, DW
中科院分区：
文献类型：
--
作者：
Fallon, PG;Gibbons, J;Dunne, DW
成人和儿童对血吸虫病的易感性存在差异。年龄依赖性先天抵抗力和获得性免疫对血吸虫病易感性差异的相对影响在人类中很难评估。因此，我们将幼年和成年雌性恒河猴暴露于曼氏血吸虫的初次感染。与成年动物相比，幼年恒河猴在血吸虫感染后外周血单核细胞产生的白细胞介素（IL）-4和IL-5水平较低，寄生虫抗原特异性抗体（IgG、IgM和IgA）反应水平较低，并产生有限的抗原特异性或总IgE。与成年动物相比，幼年动物的蠕虫负荷和组织或粪便虫卵计数增加无统计学意义，而受感染的幼年猴中循环血吸虫抗原显着较高。这些结果表明，幼年恒河猴在原发性血吸虫感染后，2 型细胞因子反应降低，并且可能更容易受到寄生虫感染。
Adults and children have differences in their susceptibility to schistosomiasis. The relative influences of age-dependent innate resistance and acquired immunity in the differences between susceptibility to schistosomiasis are difficult to assess in humans. Therefore, we exposed juvenile and adult female rhesus monkeys to primary infection with Schistosoma mansoni. In contrast to the adult animals, the juvenile rhesus monkeys had low levels of interleukin (IL)-4 and IL-5 production by peripheral blood mononuclear cells after schistosome infection, as well as lower levels of parasite-antigen-specific antibody (IgG, IgM, and IgA) responses, and produced limited antigen-specific or total IgE. Juvenile animals had statistically nonsignificant increased worm burdens and tissue or fecal egg counts, compared with that of adults, whereas circulating schistosome antigens were significantly higher in infected juvenile monkeys. These results suggest that juvenile rhesus monkeys have reduced type 2 cytokine responses after primary schistosome infections and perhaps are more susceptible to parasite infection.