Interleukin-1: A key inflammatory mediator in psoriasis?
Interleukin-1: A key inflammatory mediator in psoriasis?
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DOI：
10.1016/j.cyto.2005.12.001
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发表时间：
2006-01-21
期刊：
影响因子：
3.8
通讯作者：
Groves, RW
中科院分区：
文献类型：
--
作者：
Mee, JB;Cork, MJ;Groves, RW
促炎细胞因子白细胞介素-1（IL-1）在体内由角质形成细胞组成型表达，并已显示在银屑病皮损皮肤中表达。为了确定IL-1系统在银屑病炎症过程中的作用，对从病变和非病变皮肤切除的活检组织进行了半定量RT-PCR和cRNA微阵列研究。虽然IL-1 α mRNA水平在一部分患者中显示病变皮肤减少，但稳态IL-1 β mRNA显著增加。两种IL-1受体转录物和总IL-1受体拮抗剂均未在病变内表现出重大变化。IL-1诱导的趋化因子IL-8的表达仅在病变表皮中观察到。比较银屑病皮损皮肤和IL-1刺激的角质形成细胞的转录组谱的功能基因组实验显示了惊人的重叠水平。综上所述，这些数据表明，IL-1可能是一个重要的介体在银屑病斑块的启动和维持，并可能代表一个有吸引力的治疗目标。(c)2005爱思唯尔有限公司保留所有权利。
The pro-inflammatory cytokine interleukin-1 (IL-1) is constitutively expressed by keratinocytes in vivo and has been shown to be expressed in psoriatic lesional skin. To determine what role the IL-1 system might contribute to the inflammatory process in psoriasis, semi-quantitative RT-PCR and cRNA microarray studies were performed on biopsies excised from lesional and non-lesional skin. Whilst IL-1 alpha mRNA levels showed a reduction in lesional skin in a subset of patients, steady state IL-1 beta mRNA was increased markedly. Neither of the two IL-1 receptor transcripts nor total IL-1 receptor antagonist exhibited major changes within the lesion. Expression of the IL-1-induced chemokine IL-8 was only observed in lesional epidermis. Functional genomic experiments comparing transcriptome profiles derived from psoriatic lesional skin and IL-1 stimulated keratinocytes demonstrated a striking level of overlap. Taken together, these data suggest that IL-1 is likely to be an important mediator in the initiation and maintenance of psoriatic plaques and may represent an attractive therapeutic target. (c) 2005 Elsevier Ltd. All rights reserved.