Characteristics, comorbidities, 30-day outcome and in-hospital mortality of patients hospitalised with COVID-19 in a Swiss area - a retrospective cohort study
Characteristics, comorbidities, 30-day outcome and in-hospital mortality of patients hospitalised with COVID-19 in a Swiss area - a retrospective cohort study
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DOI：
10.4414/smw.2020.20314
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发表时间：
2020-07-14
影响因子：
2.9
通讯作者：
Govind, Sridharan
中科院分区：
文献类型：
--
作者：
Charlotte, Pellaud;Gael, Grandmaison;Govind, Sridharan
背景：自2019年12月首次描述以来，冠状病毒病19（COVID-19）已在全球范围内传播。关于需要住院治疗的瑞士患者的特征和结局的信息有限。此外，症状发作后30天和出院后的结局尚未描述。目的：描述瑞士地区因COVID-19住院的一组患者的临床特征、症状发作后30天的结局和院内死亡率。方法：在这项回顾性队列研究中，我们纳入了2020年3月1日至4月12日期间在瑞士地区（弗里堡）的公立医院网络中因微生物确诊的COVID-19而住院的所有住院患者。记录人口统计学数据、合并症和结局。率潜在的医院获得性感染，结果发病后30天的症状和住院死亡率reported.RESULTS：一百九十六例患者被纳入本研究。在我们的人群中，119例（61%）为男性，中位年龄为70岁。49例患者（25%）入住重症监护室（ICU）。潜在的医院获得性感染率为7%。总体而言，症状发作后30天，117例患者（60%）返回家中，23例患者（12%）在康复机构，18例患者（9%）在内科病房，6例患者（3%）在ICU，32例患者（16%）死亡。在30天内返回家中的患者中，73名患者（63%）报告了持续症状。总住院死亡率为17%。结论：我们报告了第一批因COVID-19住院的瑞士患者。在出现症状30天后，60%的人回家了。其中63%仍有症状。需要进行更长时间的随访研究，以记录因COVID-19住院的患者的长期结局。
BACKGROUND: Since its first description in December 2019, coronavirus disease 19 (COVID-19) has spread worldwide. There is limited information about presenting characteristics and outcomes of Swiss patients requiring hospitalisation. Furthermore, outcomes 30 days after onset of symptoms and after hospital discharge have not been described.AIMS: To describe the clinical characteristics, outcomes 30 days after onset of symptoms and in-hospital mortality of a cohort of patients hospitalised for COVID-19 in a Swiss area.METHODS: In this retrospective cohort study, we included all inpatients hospitalised with microbiologically confirmed COVID-19 between 1 March and 12 April 2020 in the public hospital network of a Swiss area (Fribourg). Demographic data, comorbidities and outcomes were recorded. Rate of potential hospital-acquired infection, outcomes 30 days after onset of symptoms and in-hospital mortality are reported.RESULTS: One hundred ninety-six patients were included in the study. In our population, 119 (61%) were male and the median age was 70 years. Forty-nine patients (25%) were admitted to the intensive care unit (ICU). The rate of potential hospital-acquired infection was 7%. Overall, 30 days after onset of symptoms 117 patients (60%) had returned home, 23 patients (12%) were in a rehabilitation facility, 18 patients (9%) in a medical ward, 6 patients (3%) in ICU and 32 (16%) patients had died. Among patients who returned home within 30 days, 73 patients (63%) reported persistent symptoms. The overall in-hospital mortality was 17%.CONCLUSION: We report the first cohort of Swiss patients hospitalised with COVID-19. Thirty days after onset of the symptoms, 60% had returned home. Among them, 63% still presented symptoms. Studies with longer follow-up are needed to document long-term outcomes in patients hospitalised with COVID-19.