SARS-CoV-2 causing pneumonia-associated respiratory disorder (COVID-19): diagnostic and proposed therapeutic options
SARS-CoV-2 causing pneumonia-associated respiratory disorder (COVID-19): diagnostic and proposed therapeutic options
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DOI：
10.26355/eurrev_202004_20871
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发表时间：
2020-04-01
影响因子：
3.3
通讯作者：
Lee, S. S.
中科院分区：
文献类型：
--
作者：
Chakraborty, C.;Sharma, A. R.;Lee, S. S.
SARS-CoV-2是导致中国武汉市爆发严重呼吸道疾病（COVID-19）的原因，目前正在全球迅速蔓延。COVID-19的迅速爆发及其在没有任何可控措施的情况下迅速传播，说明了形势的严重性。在这场危机中，关于COVID-19临床诊断和管理进展的集体知识库是一个先决条件。在这里，我们总结了所有可用的多学科方法的最新进展，以促进诊断和建议的治疗策略，为COVID-19。此外，该综述还讨论了COVID-19的不同方面，包括其流行病学;潜伏期;患者的一般临床特征;重症监护病房（ICU）患者的临床特征;存在共病的SARS-CoV-2感染以及感染SARS-CoV-2的儿科患者的临床特征。各种诊断方法的进展，如使用实时聚合酶链反应（RTPCR），胸部X线摄影和计算机断层扫描（CT）成像;和其他现代诊断方法，这种感染已被强调。然而，由于缺乏足够的证据，目前还没有正式批准的药物或疫苗可用于SARS-CoV-2。此外，我们已讨论不同类别的COVID-19治疗策略，例如预防疾病的药物（抗病毒药物及抗细胞因子）疗法的可能治疗计划。最后，对SARS-CoV-2感染疫苗的潜在候选者进行了描述。总的来说，该综述概述了SARS-CoV-2感染爆发沿着COVID-19诊断和治疗的最新进展和策略。
SARS-CoV-2 is responsible for the outbreak of severe respiratory illness (COVID-19) in Wuhan City, China and is now spreading rapidly throughout the world. The prompt outbreak of COVID-19 and its quick spread without any controllable measure defines the severity of the situation. In this crisis, a collective pool of knowledge about the advancement of clinical diagnostic and management for COVID-19 is a prerequisite. Here, we summarize all the available updates on the multidisciplinary approaches for the advancement of diagnosis and proposed therapeutic strategies for COVID-19. Moreover, the review discusses different aspects of the COVID-19, including its epidemiology; incubation period; the general clinical features of patients; the clinical features of intensive care unit (ICU) patients; SARS-CoV-2 infection in the presence of co-morbid diseases and the clinical features of pediatric patients infected with the SARS-CoV-2. Advances in various diagnostic approaches, such as the use of real-time polymerase chain reaction (RTPCR), chest radiography, and computed tomography (CT) imaging; and other modern diagnostic methods, for this infection have been highlighted. However, due to the unavailability of adequate evidence, presently there are no officially approved drugs or vaccines available against SARS-CoV-2. Additionally, we have discussed various therapeutic strategies for COVID-19 under different categories, like the possible treatment plans with drug (antiviral drugs and anti-cytokines) therapy for disease prevention. Lastly, potentials candidates for the vaccines against SARS-CoV-2 infection have been described. Collectively, the review provides an overview of the SARS-CoV-2 infection outbreak along with the recent advancements and strategies for diagnosis and therapy of COVID-19.