Chronic pulmonary infection with Stenotrophomonas maltophilia and lung function in patients with cystic fibrosis
Chronic pulmonary infection with Stenotrophomonas maltophilia and lung function in patients with cystic fibrosis
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DOI：
10.1016/j.jcf.2011.03.006
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发表时间：
2011-09-01
影响因子：
5.2
通讯作者：
Johansen, H. K.
中科院分区：
文献类型：
--
作者：
Dalboge, C. S.;Hansen, C. R.;Johansen, H. K.
背景：慢性嗜麦芽窄食单胞菌感染在囊性纤维化（CF）患者中的临床后果仍不清楚。
方法：纳入2008年1月1日至2009年12月31日在哥本哈根CF中心接受治疗的所有患者（N = 278）。将每例慢性感染嗜麦芽窄食单胞菌至少2年且无任何其他慢性革兰阴性菌感染的患者与两名未感染的CF对照者进行匹配。
结果：在2年的研究期间，21例患者慢性感染嗜麦芽窄食单胞菌。15例感染至少2年。与未感染的CF对照者相比，嗜麦芽窄食单胞菌组患者的第一秒用力呼气容积（FEV1）下降更陡（-3.2%/年对 -0.3%/年）（P = 0.03）。下降速率与患者慢性感染前3年所观察到的相同。
讨论：与慢性感染前的时期相比，慢性嗜麦芽窄食单胞菌感染不会导致肺功能更陡的下降。（C）2011欧洲囊性纤维化协会。由爱思唯尔出版集团出版。保留所有权利。
Background: The clinical consequences of chronic Stenotrophomonas maltophilia infection in cystic fibrosis (CF) patient are still unclear.Method: All patients treated in the Copenhagen CF centre (N=278) from 1 January 2008 to 31 December 2009 were included. Each patient chronically infected with S. maltophilia for at least 2 years without any other chronic Gram-negative infection were matched to two non-infected CF controls.Results: Twenty-one patients were chronically infected with S. maltophilia during the 2-year study period. Fifteen were infected for at least 2 years. The patients in the S. maltophilia group had a steeper decline (-3.2%/year vs. -0.3%/year) in FEV1 compared to the non-infected CF controls (P=0.03). The rate of decline was the same as observed 3 years before the patients became chronically infected.Discussions: Chronic infection with S. maltophilia does not lead to a steeper decline in lung function when compared to the period before chronic infection. (C) 2011 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.