Nano-emulsion production by sonication and microfluidization - A comparison
Nano-emulsion production by sonication and microfluidization - A comparison
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DOI：
10.1080/10942910600596464
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发表时间：
2006-01-01
影响因子：
2.9
通讯作者：
Bhandari, Bhesh
中科院分区：
文献类型：
--
作者：
Jafari, Seid Mahdi;He, Yinghe;Bhandari, Bhesh
在这项研究中，超声处理和微流化生产纳米乳液的效率进行了评估。目的是生产d-柠檬烯的水包油纳米乳液，以将其应用于下一步的纳米颗粒包封。在挥发性物质的包封和保留或微胶囊化效率方面，乳液粒径是关键因素之一。在本研究中，使用台式超声仪和空气驱动的微流化器来制备乳液。结果表明，虽然这两种方法都能够产生粒径范围为150-700 nm的纳米乳液，但微流化器产生的乳液粒径分布较窄，超声处理在操作和清洁方面更方便。在一般情况下，随着超声处理时间的增加，或微流化压力和持续时间的乳液的大小下降。然而，对于超声处理和微流化，乳化的最佳条件是必要的，超过该条件，乳液尺寸将增加或随着进一步处理几乎没有变化。
The efficiency of sonication and microfluidization to produce nano-emulsions were evaluated in this study. The purpose was to produce an oil-in-water nano-emulsion of d-limonene to apply it in the next step for nano-particle encapsulation. In the entrapment and retention of volatiles or for the microencapsulation efficiency, emulsion size is one of the critical factors. In this study, a bench-top sonicator and an air-driven microfluidizer were used to prepare the emulsions. Results show that, while both methods were capable of producing nano-emulsions of the size range of 150-700 nm, the microfluidizer produced emulsions with narrower size distributions and sonication was more convenient in terms of operation and cleaning. In general, the size of the emulsions decreased with increasing sonication time, or the microfluidization pressure and duration. However, for both sonication and microfluidization, optimal conditions were necessary for emulsification beyond which the emulsion sizes would either increase or have little change with further processing.