Substance Use, Violence, and Antiretroviral Adherence: A Latent Class Analysis of Women Living with HIV in Canada
Substance Use, Violence, and Antiretroviral Adherence: A Latent Class Analysis of Women Living with HIV in Canada
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DOI：
10.1007/s10461-017-1863-x
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发表时间：
2018-03-01
影响因子：
4.4
通讯作者：
Kaida, Angela
中科院分区：
文献类型：
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作者：
Carter, Allison;Roth, Eric Abella;Kaida, Angela
我们使用潜在类别分析来确定加拿大1363名感染艾滋病毒的妇女的药物使用模式，并评估与社会经济边缘化、暴力和联合抗逆转录病毒治疗（cART）的次优依从性的关联。确定了一个六类模型，包括：戒酒者（26.3%），烟草使用者（8.81%），酒精使用者（31.9%），“社会上可接受的”多物质使用者（13.9%），非法多物质使用者（9.81%）和非法多种物质使用者的所有类型（9.27%）。多项逻辑回归显示，最近经历暴力的妇女在所有物质使用潜在类别中的成员比例显着较高，相对于戒酒者，而那些报告次优cART依从性的妇女仅在多种物质使用类别中的成员比例较高。与所有类型的非法多种物质使用者显著相关的因素是性少数地位，低收入和低弹性。调查结果强调，需要增加对使用药物的妇女的社会和结构支持，以支持她们在艾滋病毒感染者中过上安全和健康的生活。
We used latent class analysis to identify substance use patterns for 1363 women living with HIV in Canada and assessed associations with socio-economic marginalization, violence, and sub-optimal adherence to combination antiretroviral therapy (cART). A six-class model was identified consisting of: abstainers (26.3%), Tobacco Users (8.81%), Alcohol Users (31.9%), 'Socially Acceptable' Poly-substance Users (13.9%), Illicit Poly-substance Users (9.81%) and Illicit Poly-substance Users of All Types (9.27%). Multinomial logistic regression showed that women experiencing recent violence had significantly higher odds of membership in all substance use latent classes, relative to Abstainers, while those reporting sub-optimal cART adherence had higher odds of being members of the poly-substance use classes only. Factors significantly associated with Illicit Poly-substance Users of All Types were sexual minority status, lower income, and lower resiliency. Findings underline a need for increased social and structural supports for women who use substances to support them in leading safe and healthy lives with HIV.