THE GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTORS
THE GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTORS
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DOI：
10.1126/science.2990035
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
METCALF, D
中科院分区：
文献类型：
--
作者：
METCALF, D
粒细胞-巨噬细胞集落刺激因子是一种特有的糖蛋白，它们相互作用，控制血液中两个相关的白细胞群体--粒细胞和单核巨噬细胞--的产生、分化和功能。这些调节剂在体内广泛产生，可能在抵抗感染方面发挥着重要作用。髓系白血病细胞的增殖仍然依赖于集落刺激因子的刺激，尽管其中一种因子也有通过诱导终末分化来抑制白血病群体的能力。
The granulocyte-macrophage colony-stimulating factors are well-characterized specific glycoproteins that interact to control the production, differentiation, and function of two related white cell populations of the blood, the granulocytes and monocyte-macrophages. Widely produced in the body, these regulators probably play an important role in resistance to infections. The proliferation of myeloid leukemia cells remains dependent on stimulation by colony-stimulating factors, although one of them also has the ability to suppress leukemic populations by inducing terminal differentiation.