Chicken industry strategies for control of tumor virus infections
Chicken industry strategies for control of tumor virus infections
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DOI：
10.1093/ps/77.8.1213
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发表时间：
1998-08-01
期刊：
影响因子：
4.4
通讯作者：
Kreager, KS
中科院分区：
文献类型：
--
作者：
Kreager, KS
马立克氏病（MD）和淋巴细胞白血病（LL）是两种不同的病毒性疾病，导致肿瘤死亡的鸡。马立克氏病是横向传播的，通过生物安全措施和疫苗接种得到控制。在疫苗免疫力建立之前预防早期暴露是最重要的。一些多户种植农场已转为所有单龄安置，以打破持续的传播周期。针对MD的疫苗接种包括活疫苗的卵内或日龄接种，包括单一或多种血清型产品。田间病毒似乎随着时间的推移而适应，并对流行的疫苗产生耐药性。Rispens疫苗（CVI-988）对美国最近出现的极强毒MD毒株显示出良好的疗效。宿主对MD的遗传抗性和对其他免疫抑制性疾病的控制也影响MD的易感性。类血友病性白血病主要是垂直传播的，因此通过在初级饲养员水平消除产蛋鸡来控制。根据遗传类型，通过从种畜中根除LL病毒，可大大提高产蛋鸡的商业性能。
Marek's disease (MD) and lymphoid leukosis (LL) are two distinct viral diseases that cause tumor mortality in chickens. Marek's disease, being horizontally transmitted, is controlled through biosecurity measures and vaccination. Prevention of early exposure before vaccine immunity is established is most important. Some multi-house growing farms have converted to all single-age placements to break the ongoing cycle of transmission. Vaccination against MD involves either in ovo or day-old administration of live vaccine, including single or multiple serotype products. Field viruses appear to adapt over time and become resistant to the prevalent vaccine. The Rispens vaccine (CVI-988) has shown good efficacy against recently emerging very virulent MD strains in the U.S. Genetic resistance of the host to MD and control of other immunosuppressive diseases also affects MD susceptibility.Lymphoid leukosis is primarily vertically transmitted and is therefore controlled by elimination of shedder hens at the primary breeder level. Depending upon the genetic type, commercial performance of laying hens may be greatly improved by eradication of the LL virus from the breeding stock.