Cardiac morphology in rats with growth hormone-producing tumours.
Cardiac morphology in rats with growth hormone-producing tumours.
复制标题
患有生长激素产生肿瘤的大鼠的心脏形态。
DOI：
10.1016/s0022-2828(85)80042-0
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发表时间：
1985
影响因子：
5
通讯作者：
Fishbein,MC
中科院分区：
文献类型：
--
作者：
Gilbert,PL;Siegel,RJ;Melmed,S;Sherman,CT;Fishbein,MC
肢端肥大症患者常见心脏增大和功能障碍。这些变化是否是生长激素过量的直接结果，被肢端肥大症患者高频率的高血压、糖尿病或动脉粥样硬化所掩盖。在这项研究中，生长激素（GH）对心脏的慢性升高的影响进行了研究，在大鼠与生长激素产生肿瘤皮下植入4周。采用几何测量和组织学检测心脏变化的存在。在荷瘤动物中观察到质量增加。与对照组相比，荷瘤大鼠右心室重量（0.17±0.03 v.0.13 ±0.01 g）和左心室重量（0.62±0.05 v.0.50 ±0.04 g）、心脏外径和心肌纤维直径（9.4±0.6 v.8.3 ±0.4μm）显著增大（P<0.05）。然而，这些增加与荷瘤组的体重增加呈线性相关，两组中心室重量与体重的比值相似。此外，在荷瘤大鼠中不存在诸如心肌纤维化或不对称间隔肥大的病理变化。因此，在本研究的条件下，生长激素过量诱导心脏生长，这似乎代表全身生长的表现，而不是明显的病理过程。
Cardiac enlargement and dysfunction are common in patients with acromegaly. Whether these changes are a direct consequence of growth hormone excess is obscured by the high frequency of hypertension, diabetes mellitus, or atherosclerosis in acromegalic patients. In this study, the effect of chronic elevations of growth hormone (GH) upon the heart were studied in rats with GH-producing tumours implanted subcutaneously for 4 weeks. Geometric measurements and histology were employed to detect the presence of cardiac changes. Increased mass was observed in the tumour-bearing animals. When compared with controls, in tumour-bearing rats there were significantly greater (P<0.05) right (0.17±0.03 v. 0.13±0.01 g) and left (0.62±0.05 v. 0.50±0.04 g) ventricular weights, external cardiac dimensions, and myocardial fibre diameters (9.4±0.6 v. 8.3±0.4μm). However, these increases were linearly-related to increased body mass in the tumour-bearing group to that the ratios of ventricular weights to body weight were similar in both groups. Furthermore, no pathologic changes such as myocardial fibrosis or asymmetric septal hypertrophy were present in the tumour-bearing rats. Thus, under the conditions of this study, growth hormone excess induced cardiac growth, which appeared to represent a manifestation of generalized body growth rather than a distinct pathologic process.