Selective Dissociation Between Core and Extended Regions of the Face Processing Network in Congenital Prosopagnosia
Selective Dissociation Between Core and Extended Regions of the Face Processing Network in Congenital Prosopagnosia
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DOI：
10.1093/cercor/bht007
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发表时间：
2014-06-01
期刊：
影响因子：
3.7
通讯作者：
Behrmann, Marlene
中科院分区：
文献类型：
--
作者：
Avidan, Galia;Tanzer, Michal;Behrmann, Marlene
越来越多的人认为，准确和有效的人脸识别是由一个神经回路组成的后部“核心”和前部的“扩展”区域。在这里，我们的特点是分布式的人脸网络在人类个体先天性面容失认症（CP）-终身障碍的脸处理相对于匹配的控制。使用功能磁共振成像，我们首先发现在CP的后核心面补丁在很大程度上正常的激活模式。我们还记录了杏仁核的正常活动（情绪处理）以及杏仁核和核心区域之间的正常甚至增强的功能连接。重要的是，在同一个人中，前颞叶皮层（身份处理）的激活减少，该区域与后核心区域之间的连接中断。在没有视觉刺激的情况下，在任务相关的面部扫描和静息状态扫描期间，前颞叶和杏仁核的神经轮廓之间的分离是明显的。两者合计，这些研究结果阐明了选择性中断在CP的神经回路，并提供了一个已知的差分困难的身份与情感表达识别在许多个人与CP的解释。
There is growing consensus that accurate and efficient face recognition is mediated by a neural circuit composed of a posterior "core" and an anterior "extended" set of regions. Here, we characterize the distributed face network in human individuals with congenital prosopagnosia (CP)-a lifelong impairment in face processing-relative to that of matched controls. Using functional magnetic resonance imaging, we first uncover largely normal activation patterns in the posterior core face patches in CP. We also document normal activity of the amygdala (emotion processing) as well as normal or even enhanced functional connectivity between the amygdala and the core regions. Critically, in the same individuals, activation of the anterior temporal cortex (identity processing) is reduced and connectivity between this region and the posterior core regions is disrupted. The dissociation between the neural profiles of the anterior temporal lobe and amygdala was evident both during a task-related face scan and during a resting state scan, in the absence of visual stimulation. Taken together, these findings elucidate selective disruptions in neural circuitry in CP and offer an explanation for the known differential difficulty in identity versus emotional expression recognition in many individuals with CP.