Determination of regional brain temperature using proton magnetic resonance spectroscopy to assess brain-body temperature differences in healthy human subjects
Determination of regional brain temperature using proton magnetic resonance spectroscopy to assess brain-body temperature differences in healthy human subjects
复制标题
DOI：
10.1002/mrm.21100
复制
发表时间：
2007-01-01
影响因子：
3.3
通讯作者：
Kauppinen, Risto A.
中科院分区：
文献类型：
--
作者：
Childs, Charmaine;Hiltunen, Yrjo;Kauppinen, Risto A.
用质子磁共振波谱(H-1MRS)对健康志愿者的脑温进行了测定。在3T时，从四个不同的灰质(GM)/白质(WM)体积获取部分水抑制的H-1MRS数据集。大脑温度是通过2.01ppm的N-乙酰天冬氨酸(NAA)的CH3与水之间的化学位移差来确定的。在2x2x2 cm(3)的H-1MRS体素中，脑温度没有明显的异质性。将来自单体素光谱学的体积平均温度与从口腔、鼓室和颞动脉区域获得的体温进行比较。平均脑实质温度比从三个脑外部位获得的读数低0.5摄氏度(P<；0.01)。从包含单体素体积的切片中获取H-1MRS成像(MRSI)数据，以评估光谱成像确定成像切片内局部脑温度的能力。在同一脑区，MRSI测定的远离大脑中心的脑温与单体素MRS测定的结果不同，可能是由于MRSI的线宽(LW)较差所致。根据提出的脑-体温度梯度和使用H-1磁共振成像监测病理中的大脑温度，如脑创伤，讨论了这些数据。
Proton magnetic resonance spectroscopy (H-1 MRS) was used to determine brain temperature in healthy volunteers. Partially water-suppressed H-1 MRS data sets were acquired at 3T from four different gray matter (GM)/white matter (WM) volumes. Brain temperatures were determined from the chemical-shift difference between the CH3 of N-acetyl aspartate (NAA) at 2.01 ppm and water. Brain temperatures in H-1 MRS voxels of 2 x 2 x 2 cm(3) showed no substantial heterogeneity. The volume-averaged temperature from single-voxel spectroscopy was compared with body temperatures obtained from the oral cavity, tympanum, and temporal artery regions. The mean brain parenchyma temperature was 0.5 degrees C cooler than readings obtained from three extra-brain sites (P < 0.01). H-1 MRS imaging (MRSI) data were acquired from a slice encompassing the single-voxel volumes to assess the ability of spectroscopic imaging to determine regional brain temperature within the imaging slice. Brain temperature away from the center of the brain determined by MRSI differed from that obtained by single-voxel MRS in the same brain region, possibly due to a poor line width (LW) in MRSI. The data are discussed in the light of proposed brain-body temperature gradients and the use of H-1 MRSI to monitor brain temperature in pathologies, such as brain trauma.