Differential control of renal and splenic nerves without medullary topography.
Differential control of renal and splenic nerves without medullary topography.
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无髓质地形的肾和脾神经的差异控制。
DOI：
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发表时间：
1991
影响因子：
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通讯作者：
Lynne C. Weaver
中科院分区：
文献类型：
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作者：
D. J. Beluli;Lynne C. Weaver
我们实验室以前的一项研究表明，药物阻断延髓头端腹外侧区的神经元比脾神经对肾脏的电活动有更大的影响(K.Hayes和L.C.Weaver，J.Physiol)。朗德。428：371-385,1990)。这种支配不同器官的交感神经的不同控制可能是由于肾和脾在控制血管的延髓神经元内的内脏表现。在乌拉坦麻醉的大鼠延髓腹外侧部，微量注射15nL(2.5nmol)兴奋性氨基酸同型半胱氨酸(DLH)。在吻侧和尾侧VLM内未发现明显的内脏组织。然而，肾神经反应始终大于脾的固定比例。总之，刺激吻侧和尾侧VLM神经元引起不同的肾和脾兴奋性反应，但提供这种选择性控制的机制不涉及VLM神经元群的空间组织。
A previous study in our laboratory showed that pharmacological blockade of neurons in the rostral ventrolateral medulla has greater influence on the electrical activity of renal than splenic nerves (K. Hayes and L. C. Weaver, J. Physiol. Lond. 428: 371-385, 1990). This differential control of sympathetic nerves innervating different organs may be due to viscerotopic representation of the kidney and spleen within medullary neurons that control the vasculature. To search for this topographical organization, 15 nl (2.5 nmol) of the excitatory amino acid DL-homocysteic acid (DLH) was microinjected into the ventrolateral medulla (VLM) of rats anesthetized with urethan. No distinct viscerotopic organization was found in the rostral or caudal VLM. However, renal nerve responses were consistently greater than splenic by a fixed proportion. In summary, stimulation of rostral and caudal VLM neurons causes differential renal and splenic excitatory responses, but mechanisms providing this selective control do not involve spatial organization of neuronal groups in the VLM.