Austrian Moderate Altitude Study 2000 (AMAS 2000).: The effects of moderate altitude (1,700 m) on cardiovascular and metabolic variables in patients with metabolic syndrome
Austrian Moderate Altitude Study 2000 (AMAS 2000).: The effects of moderate altitude (1,700 m) on cardiovascular and metabolic variables in patients with metabolic syndrome
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DOI：
10.1007/s00421-002-0736-8
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发表时间：
2003-02-01
影响因子：
3
通讯作者：
Humpeler, E
中科院分区：
文献类型：
--
作者：
Schobersberger, W;Schmid, P;Humpeler, E
我们调查了代谢综合征患者在奥地利阿尔卑斯山1700英寸的3周逗留期间的心血管系统[24小时动态血压(BP)和心率(HR)]、血糖参数和血脂代谢的变化。研究对象为代谢综合征男性受试者22例。基线调查在因斯布鲁克进行(海拔500人)。在为期3周的高原停留期间，参与者模拟了一个有适度体育活动的假期。分别于第1、4、9、19天进行检查。返回因斯布鲁克后，分别于7~10天和6~7周进行高原后检查。24小时动态血压和动态心电图显示平均心率、血压和心率压乘积(RPP：收缩压×心率)在高原暴露3周后下降。在一些患者中，与开始暴露在中等海拔地区相比，在结束时观察到室性早搏增加。心电图未见缺血性ST段改变。在研究期间，通过症状限制的最大循环功率试验测量的最大体能保持不变。高原暴露6周后，血压再次升高，并恢复到试验前水平。稳态模型评估指数(衡量胰岛素抵抗的指标)在高原停留后显著降低，口服葡萄糖耐量试验后获得的血糖浓度明显低于基础值。我们得出的结论是，在中等海拔地区暴露了3周后，代谢综合征患者(1)可以忍受他们的逗留，没有任何身体问题，(2)对心血管系统表现出短期的有利影响，(3)血糖参数有显著改善，与高密度脂蛋白胆固醇的显著增加相平行。
We investigated the changes in the cardiovascular system [resting blood pressure (BP) and heart rate (HR), measured by means of a 24-h ambulatory BP and a holter-electrocardiogram (ECG)], glycemic parameters, and lipid metabolism of subjects suffering from metabolic syndrome during a 3-week sojourn at 1,700 in in the Austrian Alps. A total of 22 male subjects with metabolic syndrome were selected. Baseline investigations were performed at Innsbruck (500 in above sea level). During the 3-week altitude stay the participants simulated a holiday with moderate sports activities. Examinations were performed on days 1, 4, 9, and 19. After returning to Innsbruck, post-altitude examinations were conducted after 7-10 days and 6-7 weeks, respectively. The 24-h ambulatory BP and holter ECG revealed a decrease in average HR, BP, and rate pressure product (RPP: systolic blood pressure x HR) after 3 weeks of altitude exposure. In some patients, an increase in premature ventricular beats was observed at the end compared to the beginning of the exposure to moderate altitude. The ECG revealed no ischemic ST-segment changes. Maximal physical capacity as measured by symptom-limited maximal cycle ergometry tests remained unchanged during the study. Six weeks after the altitude exposure the blood pressure increased again and returned to pretest levels. The Homeostasis Model Assessment index, which is a measure of insulin resistance, decreased significantly and glucose concentrations obtained after an oral glucose tolerance test were significantly lower after the stay at altitude compared to the basal values. We conclude that after a 3-week exposure to moderate altitude, patients with metabolic syndrome (1) tolerated their sojourn without any physical problems, (2) exhibited short-term favorable effects on the cardiovascular system, and (3) had significant improvements in glycemic parameters that were paralleled by a significant increase in high-density-lipoprotein-cholesterol.