Interactions and comparative effects of zopiclone, diazepam and lorazepam on psychomotor performance and on elimination pharmacokinetics in healthy volunteers.
Interactions and comparative effects of zopiclone, diazepam and lorazepam on psychomotor performance and on elimination pharmacokinetics in healthy volunteers.
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佐匹克隆、地西泮和劳拉西泮对健康志愿者精神运动表现和消除药代动力学的相互作用和比较影响。
DOI：
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
P. Paronen
中科院分区：
文献类型：
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作者：
V. Saano;P. P. Hansen;P. Paronen
安排了一项随机、安慰剂对照、双盲、单次给药交叉研究，以研究药物消除期佐匹克隆（7.5 mg）与两种广泛使用的苯二氮卓类（BZD）抗焦虑药地西泮（5 mg）和劳拉西泮（1 mg）之间可能的相互作用。在给药前和给药后1、6、8、12和24小时检测精神状态。同时，抽取血液样品用于测定血浆药物浓度。每种化合物的消除不受其他药物联合给药的影响。正如预期的那样，服药后一小时，精神表现受损。联合用药可增强其作用。在消除期，即给药后6和8小时，与给药前水平相比，仅佐匹克隆和劳拉西泮联合给药轻微损害性能，但与安慰剂相比无差异。积极治疗后的不良事件与安慰剂治疗后的不良事件没有显着差异。在推荐剂量7.5 mg下，佐匹克隆不会改变BZD抗焦虑药地西泮（5 mg）和劳拉西泮（1 mg）的消除药代动力学，这些BZD也不会影响佐匹克隆的消除。由于佐匹克隆的快速消除，与BZD合并给药后观察到的镇静作用增加持续时间较短。
A randomised, placebo-controlled, double blind single-dose cross-over study was arranged to investigate possible interactions between zopiclone (7.5 mg) and two widely used benzodiazepine (BZD) anxiolytics diazepam (5 mg) and lorazepam (1 mg) during the elimination phase of drugs. Psychomotor performance was tested before and 1, 6, 8, 12 and 24 hr after the drug administration. Simultaneously, blood samples were drawn for determination of plasma drug concentrations. The elimination of each compound was not altered by coadministration of other drugs. As expected, one hour after drug ingestion, psychomotor performance was impaired. The coadministration of drugs increased the effect. During the elimination phase, 6 and 8 hr after the drug intake, only zopiclone and lorazepam in combination slightly impaired performance as compared with the pretreatment levels, but there was no difference as compared with placebo. Adverse events after active treatments were not significantly different from those after placebo. At the recommended dose of 7.5 mg, zopiclone does not alter the elimination pharmacokinetics of the BZD anxiolytics diazepam (5mg) and lorazepam (1 mg), and neither is the elimination of zopiclone affected by these BZDs. Due to the rapid elimination of zopiclone, the increase in sedation seen after concurrent administration with BZDs is of short duration.
液相色谱法测定血浆中的佐匹克隆并应用于稳态监测。
DOI：
10.1016/s0378-4347(00)83646-4
发表时间：
1986
期刊：
Journal of chromatography
影响因子：
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作者：
Miller,LG;Leduc,BW;Greenblatt,DJ
通讯作者：
Greenblatt,DJ